Terra-Garcia, MaíraSouza, Cheyenne Marçal deGonçalves, Nathalia Maria FerreiraPereira, André Henrique CorreiaBarros, Patrícia Pimentel deBorges, Alessandra BühlerMiyakawa, WalterFerreira-Strixino, JulianaJunqueira, Juliana Campos2025-06-102025-06-10https://repositorio.univap.br/handle/123456789/991Photodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine (FTC) derived from chlorin e6. The objective of this study was to investigate the photodynamic effects of FTC against several clinical strains of S. mutans. Clinical isolates were obtained from patients with active carious lesions, identified by molecular analysis and subjected to PDT using laser irradiation (660 nm and 39.5 J/cm2) in planktonic and biofilm stages. We identified 11 S. mutans strains from cervical, occlusal and proximal caries. PDT mediated by FTC has totally eliminated the S. mutans cells in planktonic growth for all analyzed strains. In biofilms, PDT with FTC reached statistically significant reductions compared with the non-treated control group, at 5.4, 5.5 and 6.5 Log10 (CFU/mL), respectively, for the strains from proximal, occlusal and cervical caries. The scanning electron microscopy evaluations confirmed that PDT mediated by FTC was able to disaggregate and kill the S. mutans cells adhered to enamel surface, suggesting its potential to disinfect the dental tissues.PDFen-USArtigos de PeriódicosPhotodiagnosis and Photodynamic Therapy10.1016/j.pdpdt.2021.102303Photodynamic therapyStreptococcus mutansDental cariesFotoenticineTERRA-GARCIA, Maíra et al. Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries. Photodiagnosis and Photodynamic Therapy, v. 34, p. 1-8, 2021. Disponível em:Universidade do Vale do ParaíbaUniversidade do Estado de São PauloInstituto de Estudos Avançados