Araújo, Daniella CastroVeloso, Adriano AlonsoOliveira Filho, Renato Santos deGiraud, Marie-NoelleRaniero, Leandro JoséFerreira, Lydia MasakoBitar, Renata Andrade2025-06-132025-06-13https://repositorio.univap.br/handle/123456789/1000Early-stage detection of cutaneous melanoma can vastly increase the chances of cure. Excision biopsy followed by histological examination is considered the gold standard for diagnosing the disease, but requires long high- cost processing time, and may be biased, as it involves qualitative assessment by a professional. In this paper, we present a new machine learning approach using raw data for skin Raman spectra as input. The approach is highly efficient for classifying benign versus malignant skin lesions (AUC 0.98, 95% CI 0.97–0.99). Furthermore, we present a high-performance model (AUC 0.97, 95% CI 0.95–0.98) using a miniaturized spectral range (896–1039 cm− 1), thus demonstrating that only a single fragment of the biological fingerprint Raman region is needed for producing an accurate diagnosis. These findings could favor the future development of a cheaper and dedicated Raman spectrometer for fast and accurate cancer diagnosis.PDFen-USArtigos de PeriódicosArtificial Intelligence in Medicine10.1016/j.artmed.2021.102161Machine learningMelanomaRaman spectroscopyOptical diagnosisExplanatory modelingARAÚJO, D. C. et al. Finding reduced Raman spectroscopy fingerprint of skin samples for melanoma diagnosis through machine learning. Artificial Intelligence in Medicine, v. 120, p. 1-9, 2021. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0933365721001548.Universidade do Vale do ParaíbaUniversidade Federal de Minas GeraisUniversidade Federal de São PauloUniversity of Fribourg