Silva, Bruna Marques daBraga, Marília ToledoPassos, Juliene Cristina da SilvaCarvalho, Moisés LopesRosseti, Isabela BuenoAmorim, Laís Mayara Machado deRocha, João Batista Teixeira daSilva, Carlos AlbertoCosta, Maricilia Silva2025-06-132025-06-13https://repositorio.univap.br/handle/123456789/1006Adhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by Candida albicans. The ability of (PhSe)2 and (pCl-PhSe)2, two synthetic organic selenium (organochalcogen) compounds, to act on C. albicans virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was ana- lyzed. Both organochalcogen compounds inhibited C. albicans adhesion to HeLa cells, depend- ent on compound concentrations. (PhSe)2 (at 20 mM; p 1⁄4 0.0012) was significantly more effective than (pCl-PhSe)2 (at 20 mM; p 1⁄4 0.0183) compared with the control. (PhSe)2 inhibited biofilm for- mation and decreased biofilm viability in both early and mature biofilms more efficiently than (pCl-PhSe)2. Overall, the organochalcogen compounds, especially (PhSe)2, were demonstrated to be effective antifungal drugs against C. albicans virulence factors related to epithelial cell surface adhesion and the formation and viability of biofilms.PDFen-USArtigos de PeriódicosBiofouling10.1080/08927014.2021.1897110Candida albicansOrganochalcogenCompoundsBiofilmAntifungal therapyCell adhesionHeLa cellsSILVA, B. M. et al. (PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities. Biofouling, v. 37, n. 2, p. 235-245, 2021. Disponível em: https://www.tandfonline.com/doi/full/10.1080/08927014.2021.1897110.Universidade do Vale do ParaíbaUniversidade Federal de Santa MariaUniversidade Federal do ABC