Silva, Carlos AlbertoQuerobino, Samyr MachadoSilva, Cesar Augusto MeloCosta, Maricilia SilvaOliveira, Luis Vicente FrancoZamuner, Stella Regina2025-04-022025-04-02https://repositorio.univap.br/handle/123456789/798The crude venom of the Bothrops jararaca snake (Bj-CV) is a complex mixture of biologically active proteins that includes a variety of peptides in the low molecular weight fraction (Bj-PF). We investigated how an intramuscular injection of Bj-CV (1.2 mg kg−1) and Bj-PF (0.24 mg kg−1) influenced lung mechanics and lung and muscle inflammation in male Swiss mice 15 min, 1, 6, and 24 h after inoculation. Pressure dissipation against lung resistive components (ΔP1) rose significantly from 1 to 24 h after Bj-CV and 6–24 h after Bj-PF inoculation. Both Bj-CV and Bj-PF increased the total pressure variation of the lung (ΔPtot) 24 h after injection. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Furthermore, intramuscular inoculation of Bj-CV and Bj-PF resulted in an increase in muscle and pulmonary inflammation, as evidenced by an increase in leukocyte influx when compared to the control group. Finally, both Bj-CV and Bj-PF cause acute lung injury, as shown by pulmonary inflammation and decreased lung mechanics. Furthermore, the fact that Bj-PF produces mechanical alterations in the lungs and muscular inflammation implies that non-enzymatic compounds can cause inflammation.pdfenArtigos de PeriódicosCarlos Alberto-SilvaSamyr Machado QuerobinoCesar Augusto Melo-SilvaMaricilia Silva CostaLuis Vicente Franco OliveiraStella Regina Zamunerhttps://doi.org/10.1016/j.toxicon.2022.01.001Bothrops jararacaFT-IR spectroscopyLung inflammationPeptide fractionPulmonary mechanicSnake venomALBERTO-SILVA, C. et al. Local envenomation caused by a bioactive peptide fraction of Bothrops jararaca snake venom induces leukocyte influx in the lung and changes in pulmonary mechanics. Toxicon, [S. l.], v. 207, p. 52–59, fev. 2022. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0041010122000010.Natural and Humanities Sciences Center, Experimental Morphophysiology Laboratory Federal University of ABC (UFABC)Minas Gerais State University (UEMG), Health and Biological Sciences NucleusLaboratory of Respiratory Physiology, University of BrasiliaInstituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba- UNIVAPPós Graduate Program in Human Movement and Rehabilitation, Evangelical University of GoiasPostgraduate Program in Medicine, Universidade Nove de Julho – UNINOVE