Meccatti, Vanessa MarquesMoura, Larissa de SouzaPinto, Juliana GuerraFerreira‐Strixino, JulianaHasna, Amjad AbuFigueiredo-Godoi, Lívia Mara AlvesJunqueira, Juliana CamposMarcucci, María CristinaRamos, Lucas de PaulaCarvalho, Cláudio Antônio TalgePucci, César RogérioOliveira, Luciane Dias de2025-04-012025-04-01https://repositorio.univap.br/handle/123456789/792Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.pdfen-USArtigos de PeriódicosVanessa Marques MeccattiLarissa de Souza MouraJuliana Guerra PintoJuliana Ferreira‐StrixinoAmjad Abu HasnaLívia Mara Alves Figueiredo-GodoiJuliana Campos JunqueiraMaría Cristina MarcucciLucas de Paula RamosCláudio Antônio Talge CarvalhoCésar Rogério PucciLuciane Dias de Oliveira10.1155/2022/5837864Candida sppCurcumaMARQUES MECCATTI, V. et al. Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo. International Journal of Dentistry, [S. l.], v. 2022, p. 1–6, 1 jul. 2022. Disponível em: https://www.hindawi.com/journals/ijd/2022/5837864/.UnespUnespUnespUniversidade do Vale do ParaíbaUniversidade do Vale do ParaíbaUnespUnespUnespUnespUnespUnespUnesp