REPOSITÓRIO INSTITUCIONAL DA UNIVERSIDADE DO VALE DO PARAÍBA

O Repositório da Produção Intelectual da Univap tem como objetivo armazenar, preservar e disseminar a memória institucional, oferecendo acesso à produção científica, como trabalhos de conclusão da graduação, dissertações, tese e artigos científicos. Os dados e plano de gestão produzidos por pesquisadores e estudantes da Univap também poderão ser disponibilizados, dependendo da política de acesso do projeto em virtude de restrições impostas pelo registro de propriedade intelectual.

Ademais, o repositório tem um papel importante de divulgação das produções científicas, técnicas, culturais e artísticas da Univap.

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O Acesso Aberto online da produção intelectual não tem custo, mas pode ter restrições quanto à utilização dessas produções.

  • Artigos preprints, posprints ou publicados
  • Capítulos de livros
  • Dados de pesquisa
  • Plano de gestão de dados
  • Trabalho de Conclusão de Curso
  • Teses e Dissertações
  • Outros materiais

 

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Agora exibindo 1 - 5 de 8
  • FCS  
    Faculdade de Ciências da Saúde
  • FCSAC  
    Faculdade Sociais Aplicadas e Comunicação
  • FD  
    Faculdade de Direito
  • FEA  
    Faculdade de Educação e Artes
  • FEAU  
    Faculdade de Engenharias, Arquitetura e Urbanismo

Submissões Recentes

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Caminhos & carreiras: Guia sobre orientação profissional
(Univap) Dias, Giovanna Martins; Fernandes, Ingrid dos Santos; Martins, Marcella Gomes; Huayanca, Rafaela Komatzu; Beltrame, Elisabete Cristina Carnio
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As PANCS na Comunidade Beira Rio
(Univap) Gomes, Ana Caroline Ramos; Ramos, Antônia; Lacerda, Cecília Rosin; Santos, Denise Érika dos; Ramos, Isabel Cristina; Laura Armelin Azevedo; Sara Teixeira Borato Reis
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Evaluation of the Photodynamic Therapy with Curcumin on L. braziliensis and L. major Amastigotes
(MDPI) Pereira, André Henrique Correia; Marcolino, Luciana Maria Cortez; Pinto, Juliana Guerra; Strixino, Juliana Ferreira
Cutaneous leishmaniasis (CL) is a neglected disease prevalent in tropical countries with the ability to cause skin lesions. Photodynamic therapy (PDT) represents a specific and topical option for the treatment of these lesions. This study evaluated the response of macrophages infected with L. braziliensis and L. major to PDT with curcumin. Curcumin concentrations were evaluated in serial dilutions from 500.0 to 7.8 μg/mL using LED (λ = 450 ± 5 nm), with a light dose of 10 J/cm2. The Trypan blue viability test, ultrastructural analysis by scanning electron microscopy (SEM), mitochondrial polarity by Rhodamine 123 (Rho 123), curcumin internalization by confocal microscopy, and counting of the recovered parasites after the PDT treatment were performed. The lowest concentrations of curcumin (15.6 and 7.8 μg/mL) presented photodynamic inactivation. Cell destruction and internalization of curcumin in both macrophages and intracellular parasites were observed in microscopy techniques. In addition, an increase in mitochondrial membrane polarity and a decrease in the number of parasites recovered was observed in the PDT groups. This study indicates that PDT with curcumin has the potential to inactivate infected macrophages and might act as a basis for future in vivo studies using the parameters herein discussed.
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Plasmatic and salivary biomarkers for early diagnosis of Autism Spectrum Disorder: a systematic review
(CDRR Editors) Pinto, Mayara Moniz Vieira; Arisawa, Emília Angela Lo Schiavo; Martins, Rodrigo Alvaro Brandão Lopes; Raniero, Leandro José
Autistic Spectrum Disorder (ASD) is considered a neurological development disorder characterized by different degrees of deficit in communication, social interaction, and learning, accompanied by repetitive and stereotyped patterns of behavior. ASD diagnosis is extremely complex due to the still unknown etiopathology, the diversity of symptoms presented by the individuals, and it is carried out solely from clinical observations of the individual's behavior. This study aims to review the main plasma and salivary biomarkers currently studied for the early diagnosis of ASD. For this systematic literature review, we used the online data directory and database “Google Scholar” and “Publish Medliner” (PubMed), respectively, with the descriptors: “Autism”, “Biomarker”, “Diagnostic”, “Saliva”, and “Plasma”. We selected 564 studies in PubMed and 185 in Google Scholar, by screening the titles. After reading the abstracts, we excluded 647 studies, either due to irrelevance or because they were review articles, genetics studies or did not use plasma or saliva samples. The remaining 102 original studies were evaluated in full, and 83 were excluded. Thus, nineteen complete articles that met the inclusion criteria were included in the qualitative analysis. Results identified Cortisol, glutamate/GABA, glutathione, Lipid peroxidation, markers of oxidative stress, mitochondrial dysfunction, and pro-inflammatory cytokines, especially IL-6, as the main plasma and salivary biomarkers currently studied for the early diagnosis of ASD. However, considering that several results were controversial and inconclusive, further studies are needed to validate specific biomarkers as diagnostic tools. The current findings encourage studies that are controlled, multicentric, prospective, and of greater diagnostic precision.