Navegando por Autor "Costa, Maricilia Silva"
Agora exibindo 1 - 6 de 6
Resultados por página
Opções de Ordenação
Item Comparação da mecânica respiratória e performance muscular entre indivíduos curados de SARS-CoV-2 com tratamentodomiciliar e tratamento hospitalar(CDRR Editors) Moreira, Natália Galvão Rocha; Licurci, Maria das Graças Bastos; Nogueira, Daniel Vilela; Fagundes, Alessandra de Almeida; Costa, Maricilia SilvaIntrodução: Após a descoberta feita pelas autoridades da saúde chinesa, identificando o vírus SARS-CoV-2, houve a necessidade de maiores estudos, por se tornar pandemia. Mesmo os infectados por COVID-19 apresentarem sintomas leves ou assintomáticos, observou-se principalmente apresentações clínicas as afecções de trato respiratório e alterações musculares durante o período em que o indivíduo estava infectado, em tratamento ou pós-COVID. Deste modo, o objetivo deste estudo foi avaliar e comparar o comportamento da mecânica respiratória e performance muscular entre os indivíduos pós-COVID-19 que foram hospitalizados e daqueles que receberam tratamento domiciliar. Método: Avaliação de 13 indivíduos, na faixa etária de 25 a 65 anos, divididos em 2 grupos: Grupo 1 - pós diagnóstico de COVID-19 submetidos a internação hospitalar e Grupo 2 - pós diagnóstico de COVID-19 submetidos a tratamento domiciliar. Ambos os grupos fora do período de isolamento, sem risco de contaminação. Os indivíduos foram avaliados por manovacuometria, pico de fluxo expiratório e performance muscular. Dados apresentados em forma de média e desvio padrão, comparados entre os grupos por meio do teste T-Student com nível de significância de 5%. Resultados: houve uma diferença significativa na comparação entre as médias de PIMax do Grupo 1 entre os valores preditos (p=0,04), enquanto as outras comparações obtivemos p>0,05. Conclusão: mesmo com diversas publicações relatando as diferenças na mecânica respiratória e endurance muscular, essas diferenças não foram significativas estatisticamente no nosso trabalho, sendo melhor apresentadas com um maior número de amostra e menor tempo entre a infecção pelo COVID-19 e as avaliações.Item Diphenyl diselenide suppresses key virulence factors of Candida krusei, a neglected fungal pathogen(Taylor & Francis) Silva, Bruna Graziele Marques da; Pinto, Ana Paula; Passos, Juliene Cristina da Silva; Rocha, João Batista Teixeira da; Silva, Carlos Alberto; Costa, Maricilia SilvaCandida krusei is a candidiasis etiological agent of relevance in the clinical setting because of its intrinsic resistance to fluconazole. Also, it has opened up new paths in the area of alternative therapeutic techniques. This project demonstrated the effects of diphenyl diselenide (PhSe)2 and p-cloro diphenyl diselenide (pCl-PhSe)2, two organochalcogen compounds, on relevant virulence factors for the early stage of the C. krusei host interaction and infection process. Both com- pounds inhibited adherence of C. krusei to both polystyrene surfaces and cervical epithelial cells and biofilm formation; the structure of the biofilm was also changed in a dose-dependent man- ner. In addition, both compounds inhibited C. krusei growth, but (PhSe)2 significantly increased the time duration of the lag phase and delayed the start of the exponential phase in growth kinetics. (PhSe)2 has more potential antifungal activity than (pCl-PhSe)2 in inhibiting the adher- ence to epithelial cells, biofilm formation, and growth of C. krusei.Item Local envenomation caused by a bioactive peptide fraction of Bothrops jararaca snake venom induces leukocyte influx in the lung and changes in pulmonary mechanics(Elsevier) Silva, Carlos Alberto; Querobino, Samyr Machado; Silva, Cesar Augusto Melo; Costa, Maricilia Silva; Oliveira, Luis Vicente Franco; Zamuner, Stella ReginaThe crude venom of the Bothrops jararaca snake (Bj-CV) is a complex mixture of biologically active proteins that includes a variety of peptides in the low molecular weight fraction (Bj-PF). We investigated how an intramuscular injection of Bj-CV (1.2 mg kg−1) and Bj-PF (0.24 mg kg−1) influenced lung mechanics and lung and muscle inflammation in male Swiss mice 15 min, 1, 6, and 24 h after inoculation. Pressure dissipation against lung resistive components (ΔP1) rose significantly from 1 to 24 h after Bj-CV and 6–24 h after Bj-PF inoculation. Both Bj-CV and Bj-PF increased the total pressure variation of the lung (ΔPtot) 24 h after injection. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Furthermore, intramuscular inoculation of Bj-CV and Bj-PF resulted in an increase in muscle and pulmonary inflammation, as evidenced by an increase in leukocyte influx when compared to the control group. Finally, both Bj-CV and Bj-PF cause acute lung injury, as shown by pulmonary inflammation and decreased lung mechanics. Furthermore, the fact that Bj-PF produces mechanical alterations in the lungs and muscular inflammation implies that non-enzymatic compounds can cause inflammation.Item (PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti- biofilm activities(Taylor & Francis) Silva, Bruna Marques da; Braga, Marília Toledo; Passos, Juliene Cristina da Silva; Carvalho, Moisés Lopes; Rosseti, Isabela Bueno; Amorim, Laís Mayara Machado de; Rocha, João Batista Teixeira da; Silva, Carlos Alberto; Costa, Maricilia SilvaAdhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by Candida albicans. The ability of (PhSe)2 and (pCl-PhSe)2, two synthetic organic selenium (organochalcogen) compounds, to act on C. albicans virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was ana- lyzed. Both organochalcogen compounds inhibited C. albicans adhesion to HeLa cells, depend- ent on compound concentrations. (PhSe)2 (at 20 mM; p 1⁄4 0.0012) was significantly more effective than (pCl-PhSe)2 (at 20 mM; p 1⁄4 0.0183) compared with the control. (PhSe)2 inhibited biofilm for- mation and decreased biofilm viability in both early and mature biofilms more efficiently than (pCl-PhSe)2. Overall, the organochalcogen compounds, especially (PhSe)2, were demonstrated to be effective antifungal drugs against C. albicans virulence factors related to epithelial cell surface adhesion and the formation and viability of biofilms.Item Processo para obtenção de lipídeos pra uso em biocombustíveis utilizando a fração orgânica do lixo urbano(2024) Pradella, José Geraldo da Cruz; Vieira, Lucia; Costa, Maricilia SilvaItem Processo para produção de lipídeos para uso em biocombustíveis utilizando a fração orgânica de lixo urbano(2024) Pradella, José Geraldo da Cruz; Vieira, Lúcia; Costa, Maricilia Silva; Bosso, Geisler Chbane; Jofre, Jorge Benedito Freire; Souza, Jorge Damião de; Sousa, Juçara Cristina Pereira; Sonnewend, Lais; Barboza, Maria Antonia de Mello e Albuquerque; Couto, Rafaela; Cordeiro, Thaina Barbosa de Lima