Navegando por Assunto "Biomaterials"

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    Additive Manufacturing in Personalized Medicine: Enhancing the Development of Custom Biomodels Through 3D Scanning and Digital Rigging
    Basso, Beatriz Fernanda de Oliveira; Ortega, Leticia Martins Ramos; Ganga, Thabata; Rorato, Eduardo Keller; Lima, Mário Oliveira; Neves, Marcele Florêncio; Kunkel, Maria Elizete; Ribeirão Preto
    3D scanning technology and additive manufacturing techniques combined offer an innovative approach to creating personalized biomodels for medical applications. Biomodels, defined as mathematical, computational, or physical representations of a biological system, are increasingly being integrated into the design of medical devices, improving personalized medicine. Given its applications and growing interest, there is still a need to understand the challenges in manufacturing biomodels and a comprehensive methodology in the process of developing these 3D-scanned printed models. The objective of this paper is to investigate a fundamental methodology for developing biomodels to address complex clinical challenges, thereby enhancing precision and efficacy in medical practice. The methodology comprises a five-step process integrating 3D scanning, Computer Aided Design (CAD), Computer Aided Manufacturing (CAM), Computer Aided Engineering (CAE), and the “Rigging” technique. The results highlight the problems and promising clinical applications for the discussed methodology, notably in the manufacture of biomodels and the simulation of pathological structures. The spastic hand, proximal radius fracture, and healthy calf models demonstrated suitability for real-world application and high fidelity to their original anatomical form.
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    In vitro and in vivo evaluation of rotary-jet-spun poly(ɛ- caprolactone) with high loading of nano-hydroxyapatite
    (Springer) Andrade, Telmo M.; Mello, Daphne de Camargo Reis; Elias, Conceição de Maria Vaz; Abdala, Julia Marinzeck de Alcantara; Silva, Edmundo; Vasconcellos, Luana Marotta Reis de; Tim, Carla Roberta; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira
    Herein, poly(ɛ-caprolactone) (PCL) mats with different amounts of nanohydroxyapatite (nHAp) were produced using rotary- jet spinning (RJS) and evaluated in vitro and in vivo. The mean fiber diameters of the PCL, PCL/nHAp (3%), PCL/nHAp (5%), and PCL/nHAp (20%) scaffolds were 1847±1039, 1817±1044, 1294±4274, and 845±248nm, respectively. Initially, all the scaffolds showed superhydrophobic behavior (contact angle around of 140oC), but decreased to 80° after 30 min. All the produced scaffolds were bioactive after soaking in simulated body fluid, especially PCL/nHAp (20%). The crystallinity of the PCL scaffolds decreased progressively from 46 to 21% after incorporation of 20% nHAp. In vitro and in vivo cytotoxicity were investigated, as well as the mats’ ability to reduce bacteria biofilm formation. In vitro cellular differentiation was evaluated by measuring alkaline phosphatase activity and mineralized nodule formation. Overall, we identified the total ideal amount of nHAp to incorporate in PCL mats, which did not show in vitro or in vivo cytotoxicity and promoted lamellar bone formation independently of the amounts of nHAp. The scaffolds with nHAp showed reduced bacterial proliferation. Alizarin red staining was higher in materials associated with nHAp than in those without nHAp. Overall, this study demonstrates that PCL with nHAp prepared by RJS merits further evaluation for orthopedic applications
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    Retraction Note to: In vitro and in vivo evaluation of rotary-jet-spun poly(ɛ-caprolactone) with high loading of nano-hydroxyapatite
    (Springer) Andrade, Telmo M.; Mello, Daphne de Camargo Reis; Elias, Conceição de Maria Vaz; Abdala, Julia Marinzeck de Alcantara; Silva, Edmundo; Vasconcellos, Luana Marotta Reis de; Tim, Carla Roberta; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira