Navegando por Assunto "Plant extract"

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    Exploring Antioxidant, Antimicrobial and Anti-Inflammatory Effects of Juglans regia and Pfaffia paniculata Extracts: implications for Intestinal Dysbiosis and Colorectal Cancer Risk Associated with Oral Pathogens
    (MDPI) Miranda, Diego Garcia; Ramos, Lucas de Paula; Attik, Nina; Silva, Nicole Van Der Heijde Fernandes; Camargo, Pyetra Claro; Araujo, Gabriela Ferraz de; Lopes, Nicole Fernanda dos Santos; Marcucci, Maria Cristina; Soares, Cristina Pacheco; Godoi, Bruno Henrique; Caires, Giovanna Arruda; Vigerelli, Hugo; Carrouel, Florence
    Colorectal neoplasms rank as the third most prevalent cancer globally and stand as the second leading cause of cancer-related mortality. Its etiol- ogy is multifaceted, pointing to the role of microorganisms within the human microbiota in its development. Notably, the high prevalence of oral pathogens like Fusobacterium nucleatum and Parvimonas micra is implicated in inducing gut dysbiosis and stimulating the proliferation and metastasis of cancer cells. Therefore, this study aimed to evaluate in vitro the biological effects of extracts from Juglans regia and Pfaffia paniculata. Methods: Phytochemical analysis was carried out by HPLC, and the antioxidant effect was deter- mined by DPPH. Antimicrobial activity was investigated on F. nucleatum and P. micra planktonic and biofilms. Metabolic activity and genotoxicity were performed. Results: J. regia and P. paniculata expressed CE50 37.26 and 1367.57 mcg, respectively. The extracts exhibited a minimum bactericidal concentration of 1.73 and 0.48 mg/mL for J. regia and P. paniculata, respectively. Reduction superiorly 90% of P. micra biofilms. Metabolic activity was varied proportionally to the extract concentration, and no genotoxic effects were ob- served. Conclusions: The J. regia extract has great antioxidant activity and could be used as an alternative in combating pathogens associated with the onset of dysbiosis and tumor progression in colorectal neoplasms. Nevertheless, further studies are needed to validate their clinical applicability.
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    Green synthesis of iron nanoparticles from the baru (Dipteryx alata) endocarp extract for the efficient removal of rhodamine B and caffeine from water through the heterogeneous Fenton process
    (IWA) Corrêa, Cassiano Ricardo Reinehr; Siqueira, Adriano Buzutti de; Lopes, Paulo Renato Matos; Ambrosio, Jéssica Aparecida Ribeiro; Simioni, Andreza Ribeiro; Vasconcelos, Leonardo Gomes de; Morais, Eduardo Beraldo de
    This study presents the first-time synthesis of iron nanoparticles (FeNPs) using an aqueous extract from the baru fruit endocarp (Dipteryx alata). Characterization through scanning electron microscopy and dynamic light scattering revealed spherical shapes with an average diameter of 419.2 nm. Fourier transform infrared spectroscopy identified phytochemicals from the baru fruit extract, acting as both reducing and stabilizing agents. X-ray diffraction confirmed the amorphous nature of the FeNPs. The Fenton-like catalytic efficiency of FeNPs was investigated for degrading rhodamine B (RhB) and caffeine. The impact of crucial parameters such as pH, H2O2 dosage, nanoparticles concentration, and temperature on the degradation process was assessed. At pH 3.0, with 1.0 g L−1 of FeNPs, 1% H2O2, and 45 °C, RhB and caffeine degradation reached 99.14 and 92.01%, respectively. The catalytic reaction kinetics followed a pseudo-first-order model for caffeine and a pseudo-second-order model for RhB. Phytotoxicity studies on Cucumis sativus confirmed the non-toxic nature of the degraded products of RhB and caffeine. These findings highlight the potential of FeNPs synthesized from the baru endocarp extract as a catalyst for removing organic pollutants, suggesting promising applications in environmental remediation and related fields.