Navegando por Assunto "Sciatic functional index"

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    Analysis of Movements in Spinal Cord Hemisection Treatment with Amniotic Membrane – Preclinical Study
    (Scientific Research Publishing Inc.) Neves, Marcele Florêncio das; Fonseca, Joyce Lilian Reis da; Carvalho, Paula Cristina Simões de; Pereira, Aline Priscila Campos; Polisel, Evandro Henrique Pintor; Proglhof, Stephanie de Medeiros Passos; Sant ́Anna, Luciana Barros; Lima, Mário Oliveira; Arisawa, Emília Ângela Lo Schiavo
    Aims: This study aimed to evaluate the efficacy of Amniotic Membrane application in rats with Spinal Cord Injury induced by transverse hemisection using kinematic analysis and Sciatic Functional Index. Study design: True experimental research design. Place and Duration of Study: Instiuto de Pesquisa e Desenvolvimento (IP&D) of Universidade do Vale do Paraíba (UNIVAP), between September 2016 and December 2017. Methodology: Fifteen adult male rats were used, allocated into three equal groups: Control (the spinal cord injury and Amniotic Membrane application were simulated), Lesion (spinal cord injury not treated), Amniotic membrane (spinal cord injury treated by amniotic membrane). All animals underwent surgical procedures. A transverse hemisection was performed in groups Lesion and Amniotic Membrene. A fragment of the biomaterial was applied in group AM covering the hemisection area. Results: Sciatic Functional Index and motion analysis were performed by comparing images taken at pre- and postoperative time at 7, 14, 21, and 28 days. The kinematic analysis showed a significant difference between groups Control and Lesion at 7 days (p = 0.023) and 14 days (p = 0.015), and between groups Lesion and Amniotic Membrane at 14 days (p = 0.039), comparing the postoperative periods. The Sciatic Functional Index revealed significant differences between Groups Control and Lesion at 7 (p = -0.002), 14 (p = 0.003), and 21 days (p = 0.009), between Groups Control and Amniotic Membrane at 7 (p = 0.014), 14 (p = 0.007), and 28 days (p = 0; 013), and between Groups Lesion and Amniotic Membrane only at 14 days (p = 0.039). Conclusion: Application of amniotic membrane in spinal cord hemisection in rats induced gait recovery and improvement in SFI compared to the untreated group.
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    Kinematic and sensory-motor analysis of the effects of treatments with photobiomodulation in rats with experimentally induced spinal injury
    (Springer Nature Link) Beloni, Luís Filipe Karatanasov; Lima, Leonardo Borges de; Correia, Débora Campos Chaves; Mendes, Alessandro Corrêa; Sannt'Anna, Luciana Barros; Arisawa, Emilia Angela Lo Schiavo; Lima, Fernanda Pupio Silva; Lima, Mario Oliveira
    The aim of this study was to evaluate the kinematic and sensorimotor parameters after application of photobiomodula- tion (PBM) in rats with experimentally induced spinal cord injuries (SCI). The animals were randomly divided into 3 experimental groups containing 5 animals each and respecting the following arrangement: C (control, simulation of sur- gical procedures); I (injury, induction of SCI) and PBM (photobiomodulation, SCI+application of photobiomodulation therapy). All animals underwent movement tests after 3, 7, 10 and 14 days, respectively, after the surgical procedure, and the following movement parameters were evaluated: mean velocity (MV), ground reaction force (GRF) and sciatic func- tional index (SFI) using integrated equipment capable of digitally collecting the proposed data. The mean results of the MV data obtained by groups C, I and PBM were compared and a statistically significant difference was found, being: C x I (p=0.001) and I x PBM (p=0.002), respectively. Considering the SFI data obtained by groups C, I and PBM, a statisti- cally significant difference was observed when comparing C x I (p = 0.011). The mean results of the GRF data obtained by groups C, I and PBM were compared and the results showed a statistically significant difference in C x I (p=0.001), C x PBM (p=0.026) and I x PBM (p=0.002), respectively. Therefore, there was an improvement in motor function between the 7th and 14th day after SCI, represented by the increase in speed and better GRF distribution in the PBM group.