Sputtering of micro-carbon-silver film (μC-Ag) for endotracheal tubes to mitigate respiratory infections

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dc.contributor.authorSilva, Michely Glenda Pereira da
dc.contributor.authorManfroi, Lucas Augusto
dc.contributor.authorLobo, Larissa Zamboni
dc.contributor.authorVieira, Angela Aparecida
dc.contributor.authorMacário, Paulo Fabrício
dc.contributor.authorFukumasu, Newton Kiyoshi
dc.contributor.authorSilva, Newton Soares da
dc.contributor.authorTschiptschin, André Paulo
dc.contributor.authorMarques, Francisco das Chagas
dc.contributor.authorVieira, Lucia
dc.date.accessioned2026-01-21T14:36:07Z
dc.date.available2026-01-21T14:36:07Z
dc.date.issued22023
dc.description.abstractPolyurethane (PU) substrates are biocompatible materials widely used to manufacture endotracheal tubes. However, in common with other biomedical materials, they are liable to the formation of microbial films. The occurrence of pneumonia in intubated patients treated at intensive care units often takes the form of ventilator-associated pneumonia (VAP). The issue relates to the translocation of pathogenic microorganisms that colonize the oropharyngeal mucosa, dental plaque, stomach, and sinuses. New protective materials can provide a more effective therapeutic approach to mitigating bacterial films. This work concerns microcrystalline carbon film containing dispersed silver nanoparticles (μC-Ag) deposited on PU substrates using a physical vapor deposition sputtering process. For the first time, carbon paper was used to produce a carbon target with holes exposing a silver disk positioned under the carbon paper, forming a single target for use in the sputtering system. The silver nanoparticles were well distributed in the carbon film. The adherence characteristics of the μC-Ag film were evaluated using a tape test technique, and electron dispersive x-ray mapping was performed to analyze the residual particles after the tape test. The microbicidal effect of the thin film was also investigated using species S. aureus, a pathogenic microorganism responsible for most infections of the lower respiratory tract involving VAP and ventilator-associated tracheobronchitis (VAT). The results demonstrated that μC-Ag films on PU substrates are promising materials for mitigating pathogenic microorganisms on endotracheal tubes.
dc.description.physical10 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.uriFAPESP: 11/50773-0 CNPq: 317253/2021-2.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade de São Paulo
dc.identifier.affiliationUniversidade Estadual de Campinas
dc.identifier.bibliographicCitationSILVA, M. G. P. et al. Sputtering of micro-carbon-silver film (μC-Ag) for endotracheal tubes to mitigate respiratory infections. Biomedical Materials, v. 18, n. 2, p. 1-10, 2023. Disponível em: https://iopscience.iop.org/article/10.1088/1748-605X/acba70.
dc.identifier.doi10.1088/1748-605X/acba70
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1101
dc.language.isoen_US
dc.publisherIOP science
dc.rights.holderBiomedical Materials
dc.subject.keywordMicrocrystalline carbon film
dc.subject.keywordSilver nanoparticles
dc.subject.keywordMicrobicide
dc.subject.keywordPolyurethane
dc.titleSputtering of micro-carbon-silver film (μC-Ag) for endotracheal tubes to mitigate respiratory infections
dc.typeArtigos de Periódicos

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