Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma

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dc.contributor.authorQueiroz, João Paulo da Silva
dc.contributor.authorPUPIN, Breno
dc.contributor.authorBHATTACHARJEE, Tanmoy Tapobrata
dc.contributor.authorUNO, Miyuki
dc.contributor.authorCHAMMAS, Roger
dc.contributor.authorKULCSAR, Marco Aurélio Vamondes
dc.contributor.authorCANEVARI, Renata de Azevedo
dc.date.accessioned2024-02-23T17:54:20Z
dc.date.available2024-02-23T17:54:20Z
dc.date.issued22024-01-05
dc.description.abstractWe explore the feasibility of using FOS and JUN gene expression and ATR-FTIR for diagnosis of thyroid cancer. For the study, 38 samples (6 non-neoplastic (NN), 10 papillary thyroid carcinoma (PTC), 7 follicular thyroid carcinoma (FTC), and 15 benign tumors (BT) were subjected to RNA extraction followed by quantitative real time PCR (qRT-PCR) and 30 samples (5 NN, 9 PTC, 5 FTC, and 11 BT) were used for Attenuated Total Reflectance – Fourier Transform Infrared (ATR-FTIR) followed by multivariate analysis. Of the above, 20 samples were used for both gene expression and ATR-FTIR studies. We found FOS and JUN expression in malignant tumor samples to be significantly lower than NN and benign. ATR-FIR after multivariate analysis could identify the difficult to diagnose FTC with 93 % efficiency. Overall, results suggest the diagnostic potential of molecular biology techniques combined with ATR-FTIR spectroscopy in differentiated thyroid carcinomas (PTC and FTC) and BT.
dc.description.physical8 p.
dc.description.uriProjeto n. 2009/18440-1 Projeto n. 2013/14464-9 Projeto n. 2019/10211-5
dc.format.mimetypepdf
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationQUEIROZ, João Paulo da Silva; PUPIN, Breno; BHATTACHARJEE, Tanmoy Tapobrata; UNO, Miyuki; CHAMMAS, Roger; KULCSAR, Marco Aurélio Vamondes; CANEVARI, Renata de Azevedo. Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. v. 304, p: 123305, 2024. DOI: 1016/j.saa.2023.123305.
dc.identifier.doi10.1016/j.saa.2023.123305
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/343
dc.language.isoen_US
dc.publisherElsevier
dc.rightsAcesso Embargado
dc.rights.holderJoãao Paulo da Silva Queiroz
dc.rights.holderBreno Pupin
dc.rights.holderTanmoy Tapobrata Bhattacharjee
dc.rights.holderMiyuki Uno
dc.rights.holderRoger Chammas
dc.rights.holderMarco Auréelio Vamondes Kulcsar
dc.rights.holderRenata de Azevedo Canevari
dc.subject.keywordThyroid cancer
dc.subject.keywordGene expression
dc.subject.keywordExpressão Gênica
dc.subject.keywordSpectroscopy
dc.titleExpression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma
dc.typeArtigos de Periódicos

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