Zinc pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cells

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dc.contributor.authorOliveira Junior, Benedito Marcio de
dc.contributor.authorTeodoro, Jéssica Beatriz Miranda
dc.contributor.authorAmbrósio, Jéssica Aparecida Ribeiro
dc.contributor.authorGonçalves, Érika Peterson
dc.contributor.authorBeltrame Junior, Milton
dc.contributor.authorMarcolino, Luciana Maria Cortez
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorFerreira-Strixino, Juliana
dc.contributor.authorSimioni, Andreza Ribeiro
dc.date.accessioned2023-09-26T13:57:54Z
dc.date.available2023-09-26T13:57:54Z
dc.date.issued22021-10-23
dc.description.abstractDevelopment delivery systems, such as nanoparticles, represent a growing area in biomedical research. Nanoparticles (NP) were prepared using a double-emulsion method to load zinc(II) phthalocyanine (ZnPc). NP were obtained using poly (lactic acid) (PLA). ZnPc is a second generation of photosensitizer used in photodynamic therapy (PDT). ZnPc loaded PLA nanoparticles (NPLAZnPc) were prepared by double-emulsion method, characterized and available in cellular culture. The mean nanoparticle size presented particle size was 384.7 ± 84.2 nm with polydispersity index (PDI) of 0.150 ± 0.015, and the encapsulation efficiency was of 83%. The nanoparticle formulations presented negative zeta potential values (27.5 ± 1.0 mV), explaining their colloidal stability. ZnPc loaded nanoparticles maintain its photophysical behavior after encapsulation. Photosensitizer release from nanoparticles was sustained over 168 h with a biphasic ZnPc release profile. An in vitro phototoxic effect in range of 80% was observed in 9 L/ LacZ gliosarcoma cells at laser light doses (10 J cm2) with 3.0 mg mL1 of NPLA-ZnPc. All the physical–chemical, photophysical and photobiological measurements performed allow us to conclude that ZnPc loaded PLGA nanoparticles is a promising drug deliverysystem for PDT.pt_BR
dc.description.physical18 f.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.uriProjeto número 2018/18531-6.pt_BR
dc.format.mimetypepdfpt_BR
dc.identifier.affiliationUnivappt_BR
dc.identifier.bibliographicCitationOLIVEIRA JUNIOR, B. M., TEODORO, J. B. M., AMBRÓSIO, J. A. R., GONÇALVES, E. P., BELTRAME JUNIOR, M., MARCOLINO, L. M. C.; PINTO, J. G.; FERREIRA-STRIXINO, J.; SIMIONI, A. R. Zinc pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cells. Journal of Biomaterials Science-Polymer Edition, v. 33, n. 1, p. 93-109, Sep. 2021. (18/18531-6)pt_BR
dc.identifier.doihttps://doi.org/10.1080/09205063.2021.1980359
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/319
dc.language.isoenpt_BR
dc.publisherTaylor & Francis Grouppt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.holderOliveira Junior, Benedito Marcio dept_BR
dc.rights.holderTeodoro, Jéssica Beatriz Mirandapt_BR
dc.rights.holderAmbrósio, Jéssica Aparecida Ribeiropt_BR
dc.rights.holderGoncalves, Erika Petersonpt_BR
dc.rights.holderBeltrame Junior, Miltonpt_BR
dc.rights.holderMarcolino, Luciana Maria Cortezpt_BR
dc.rights.holderPinto, Juliana Guerrapt_BR
dc.rights.holderFerreira-Strixino, Julianapt_BR
dc.rights.holderSimioni, Andreza Ribeiropt_BR
dc.subject.keywordPhotodynamic therapypt_BR
dc.subject.keywordPolymeric nanoparticlespt_BR
dc.subject.keywordZinc phthalocyaninept_BR
dc.titleZinc pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cellspt_BR
dc.typeArtigos de Periódicospt_BR

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