Development and characterization of ceramic-polymeric hybrid scaffolds for bone regeneration: incorporating of bioactive glass BG-58S into PDLLA matrix

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dc.contributor.authorAguiar, Veronica Cristina Pêgo Fiebig
dc.contributor.authorBezerra, Rayssa do Nascimento
dc.contributor.authorSantos, Kennedy Wallace dos
dc.contributor.authorGonçalves, Isabela dos Santos
dc.contributor.authorCosta, Karen Julie Santos Grancianinov
dc.contributor.authorLauda, Diogo Ponte
dc.contributor.authorCampos, Tiago Moreira Bastos
dc.contributor.authorPrado, Renata Falchete do
dc.contributor.authorVasconcellos, Luana Marotta Reis de
dc.contributor.authorOliveira, Ivone Regina de
dc.date.accessioned2025-02-07T13:12:55Z
dc.date.available2025-02-04T19:01:01Z
dc.date.available2025-02-07T13:12:55Z
dc.date.issued22024
dc.description.abstractIn recent years, there has been a notable surge of interest in hybrid materials within the biomedical field, particularly for applications in bone repair and regeneration. Ceramic-polymeric hybrid scaffolds have shown promising outcomes. This study aimed to synthesize bioactive glass (BG-58S) for integration into a bioresorbable poly- meric matrix based on PDLLA, aiming to create a bioactive scaffold featuring stable pH levels. The synthesis involved a thermally induced phase separation process followed by lyophilization to ensure an appropriate porous structure. BG-58S characterization revealed vitreous, bioactive, and mesoporous structural properties. The scaffolds were analyzed for morphology, interconnectivity, chemical groups, porosity and pore size distribution, zeta potential, pH, in vitro degradation, as well as cell viability tests, total protein content and mineralization nodule production. The PDLLA scaffold displayed a homogeneous morphology with interconnected mac- ropores, while the hybrid scaffold exhibited a heterogeneous mor- phology with smaller diameter pores due to BG-58S filling. The hybrid scaffold also demonstrated a pH buffering effect on the polymer surface. In addition to structural characteristics, degrada- tion tests indicated that by incorporating BG-58S modified the acidic degradation of the polymer, allowing for increased total pro- tein production and the formation of mineralization nodules, indi- cating a positive influence on cell culture.
dc.description.physical19 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriFAPESP (2018/22486-6; 2019/15960-6), CNPq (305727/2021-4), and Finep (01.13.0275.00 and 01.18.0053.00).
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationInstituto Tecnológico de Aeronáutica
dc.identifier.affiliationIndustry and Commercialization of Biomechanical Devices
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.bibliographicCitationAguiar, Veronica Cristina Pêgo Fiebig et al. Development and characterization of ceramic-polymeric hybrid scaffolds for bone regeneration: incorporating of bioactive glass BG-58S into PDLLA matrix. Journal of Biomaterials Science, Polymer Edition, v. 35, n. 10, p. 1493-1510, 2024.
dc.identifier.doi10.1080/09205063.2024.2334981
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/549.2
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.rights.holderVeronica Cristina Pêgo Fiebig Aguiar
dc.rights.holderRayssa Do Nascimento Bezerra
dc.rights.holderKennedy Wallace dos Santos
dc.rights.holderIsabela dos Santos Gonçalves
dc.rights.holderKaren Julie Santos Grancianinov Costa
dc.rights.holderDiogo Ponte Lauda
dc.rights.holderTiago Moreira Bastos Campos
dc.rights.holderRenata Falchete do Prado
dc.rights.holderLuana Marotta Reis de Vasconcellos
dc.rights.holderIvone Regina de Oliveira
dc.subject.keywordScaffold
dc.subject.keywordBG-58S
dc.subject.keywordSol-gel
dc.subject.keywordPoly(D,L-lactic acid)
dc.subject.keywordCell culture
dc.titleDevelopment and characterization of ceramic-polymeric hybrid scaffolds for bone regeneration: incorporating of bioactive glass BG-58S into PDLLA matrix
dc.typeArtigos de Periódicos

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