Influence of manufacturing parameters on bioactive glass 45S5: Structural analysis and applications in bone tissue engineering

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dc.contributor.authorSantos, Kennedy Wallace dos
dc.contributor.authorCosta, Karen Julie Santos Grancianinov
dc.contributor.authorGonçalves, Isabela dos Santos
dc.contributor.authorAlves, M.
dc.contributor.authorLauda, Diogo Ponte
dc.contributor.authorVasconcellos, Luana Marotta Reis de
dc.contributor.authorCampos, Tiago Moreira Bastos
dc.contributor.authorOliveira, Ivone Regina de
dc.date.accessioned2026-01-14T18:54:16Z
dc.date.available2026-01-14T18:54:16Z
dc.date.issued22024
dc.description.abstractBioactive glass (BG-45S5) production through the melting process is affected by a wide variety of parameters. This study investigated the synthesis of BG-45S5 granules and the process variables to produce a bioactive and osteoinductive BG for bone grafting applications. The melting process was initially analyzed by varying pa- rameters such as crucible type and pouring environment using P2O5 as phosphorus precursor. The obtained products were characterized by crystalline phases, characteristic chemical groups, particle size distribution, and chemical composition. Materials poured into graphite or steel molds resulted in particle sizes more suitable for applications in granular form. Using a platinum crucible yielded a chemical composition closer to the target when compared with another ceramic crucible. Subsequently, the melting process was evaluated to different phosphorus precursor (P2O5 or Na2HPO4) and melting duration (1 or 2 h) in a platinum crucible verifying their effects on the thermal behavior, chemical composition and structure of BG-45S5. Employing Na2HPO4 as a precursor led to higher glass transition and crystallization temperatures as compared to P2O5, enhancing glass homogeneity and structural stability. The product with better characteristics in terms of composition and structure was further characterized for bioactivity and cell culture behavior, showing a greater amount of mineralization nodules when compared to commercial hydroxyapatite. This is particularly due to its behavior as the solubility and interaction in biological environments.
dc.description.physical12 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriFAPESP: 2019/15960-6 CNPq: 305727/2021-4 FINEP: 01.13.0275.00 and 01.18.0053.00
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationSELAZ
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.affiliationInstituto Tecnológico de Aeronáutica
dc.identifier.bibliographicCitationSANTOS, K. W. et al. Influence of manufacturing parameters on bioactive glass 45S5: Structural analysis and applications in bone tissue engineering. Ceramics International, v. 50, n. 23, p. 51043-51054, 2024. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0272884224044833.
dc.identifier.doi10.1016/j.ceramint.2024.10.014
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1089
dc.language.isoen_US
dc.publisherElsevier
dc.rights.holderCeramics International
dc.subject.keywordBone graft
dc.subject.keywordBioactive glass 45S5
dc.subject.keywordMelting process
dc.subject.keywordCrucible type
dc.subject.keywordPhosphorus precursor
dc.titleInfluence of manufacturing parameters on bioactive glass 45S5: Structural analysis and applications in bone tissue engineering
dc.typeArtigos de Periódicos

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