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Item Retraction Note to: In vitro and in vivo evaluation of rotary-jet-spun poly(ɛ-caprolactone) with high loading of nano-hydroxyapatite(Springer) Andrade, Telmo M.; Mello, Daphne de Camargo Reis; Elias, Conceição de Maria Vaz; Abdala, Julia Marinzeck de Alcantara; Silva, Edmundo; Vasconcellos, Luana Marotta Reis de; Tim, Carla Roberta; Marciano, Fernanda Roberta; Lobo, Anderson OliveiraItem In vitro and in vivo evaluation of rotary-jet-spun poly(ɛ- caprolactone) with high loading of nano-hydroxyapatite(Springer) Andrade, Telmo M.; Mello, Daphne de Camargo Reis; Elias, Conceição de Maria Vaz; Abdala, Julia Marinzeck de Alcantara; Silva, Edmundo; Vasconcellos, Luana Marotta Reis de; Tim, Carla Roberta; Marciano, Fernanda Roberta; Lobo, Anderson OliveiraHerein, poly(ɛ-caprolactone) (PCL) mats with different amounts of nanohydroxyapatite (nHAp) were produced using rotary- jet spinning (RJS) and evaluated in vitro and in vivo. The mean fiber diameters of the PCL, PCL/nHAp (3%), PCL/nHAp (5%), and PCL/nHAp (20%) scaffolds were 1847±1039, 1817±1044, 1294±4274, and 845±248nm, respectively. Initially, all the scaffolds showed superhydrophobic behavior (contact angle around of 140oC), but decreased to 80° after 30 min. All the produced scaffolds were bioactive after soaking in simulated body fluid, especially PCL/nHAp (20%). The crystallinity of the PCL scaffolds decreased progressively from 46 to 21% after incorporation of 20% nHAp. In vitro and in vivo cytotoxicity were investigated, as well as the mats’ ability to reduce bacteria biofilm formation. In vitro cellular differentiation was evaluated by measuring alkaline phosphatase activity and mineralized nodule formation. Overall, we identified the total ideal amount of nHAp to incorporate in PCL mats, which did not show in vitro or in vivo cytotoxicity and promoted lamellar bone formation independently of the amounts of nHAp. The scaffolds with nHAp showed reduced bacterial proliferation. Alizarin red staining was higher in materials associated with nHAp than in those without nHAp. Overall, this study demonstrates that PCL with nHAp prepared by RJS merits further evaluation for orthopedic applicationsItem A microbead-enhanced electrochemical platform for β-amyloid peptide (1–42) detection(Frontiersin) Razzino, Claudia do Amaral; Sgobbi, Lívia Flório; Cancino-Bernardi, Juliana; Zapata, Angelica Maria Mazuera; Costa, Clara Cardoso; Zucolotto, Valtencir; Vieira, Lucia; Lobo, Anderson OliveiraAlzheimer’s disease is the most prevalent form of dementia and is primarily characterized by the accumulation of β-amyloid and phosphorylated tau proteins in the brain, along with the degeneration of nerve cells, which leads to impairment of various cognitive functions. A significant biomarker of Alzheimer’s disease is the decreased level of soluble β-amyloid peptide (1–42) (Aβ1-42) in cerebrospinal fluid (CSF), as pathology progresses when CSF-Aβ1-42 levels drop below 192 pg mL-1 . In this study, we developed an amperometric immunosensor based on magnetic beads as the platform for constructing the immunosensor. Monoclonal antibodies are immobilized on the MBs, enabling selective detection of Aβ1-42. The detection antibody is conjugated with the enzyme horseradish peroxidase, which, in the presence of H2O2 and hydroquinone, catalyzes the decomposition of H2O2 and the oxidation of hydroquinone to p-quinone, generating an electric current measured at a potential of −200 mV (vs. the Ag pseudo-reference electrode) using screen-printed carbon electrodes. The amperometric sandwich-type immunosensor demonstrates a linear response in the concentration range of 10 to 10,000 pg mL-1 , with a detection limit of 7.4 pg mL-1 , exhibiting excellent selectivity against the assessed interferents. These findings suggest the potential application of this immunosensor in the early diagnosis of Alzheimer’s disease, offering a sensitive and specific tool for clinical analysis. Despite its high performance, further studies are required to validate its robustness and applicability in complex clinical samples.Item Correction: Barbosa et al. Production of rGO-Based Electrospinning Nanocomposites Incorporated in Recycled PET as an Alternative Dry Electrode. Polymers 2022, 14, 4288(MDPI) Barbosa, Michelle Chizzolini; Razzino, Claudia do Amaral; Stocco, Thiago Domingues; Santana, Moisés das Virgens; Ghosh, Anupama; Pereira, Luiz Fernando; Tierra-Criollo, Carlos Julio; Lobo, Anderson OliveiraItem Production of rGO-Based Electrospinning Nanocomposites Incorporated in Recycled PET as an Alternative Dry Electrode(MDPI) Barbosa, Michelle Chizzolini; Razzino, Claudia do Amaral; Stocco, Thiago Domingues; Santana, Moisés das Virgens; Ghosh, Anupama; Pereira, Luiz Fernando; Tierra-Criollo, Carlos Julio; Lobo, Anderson OliveiraIn this work, Coca-Cola® bottles were reused as a PET polymer (rPET) source to produce electrospun polymeric nanofibers. The nanofibers were electrospun from polymer solutions with different concentrations of reduced graphene oxide (rGO) incorporated for applications in somatosen-sory electrical stimulation. The rPET/rGO nanofiber mats were characterized by SEM, TEM, Raman, DSC, TGA, and DMA and the results showed that the incorporation of rGO in electrospun rPET fibers produced rPET/rGO composites. The rPET/rGO composites were then evaluated for possible appli- cation as dry electrodes. Moreover, with a preliminary test of numerous volunteers, the rPET/rGO dry electrode showed promising results. The rPET/rGO electrodes showed good performance and applicability to make dry electrodes, and these have applications as dry or wearable electrodes to produce electrochemical sensors.