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Item Biocomposite macrospheres based on strontium-bioactive glass for application as bone fillers(American Chemical Society) Oliveira, Ivone Regina de; Gonçalves, Isabela dos Santos; Santos, Kennedy Wallace dos; Lança, Maria Carmo; Vieira, Tânia; Silva, Jorge Carvalho; Cengiz, Ibrahim Fatih; Reis, Rui Luís; Oliveira, Joaquim Miguel; Borges, João Paulo Miranda RibeiroTraditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which can limit bone ingrowth. The use of novel biocomposite sphere formulations comprising bioactive factors as bone fillers are most advantageous, as it simultaneously allows for packing the particles in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately a superior new bone formation. In this work, we develop and characterize novel biocomposite macrospheres of Sr-bioactive glass using sodium alginate, polylactic acid (PLA), and chitosan (CH) as encapsulating materials for finding applications as bone fillers. The biocomposite macrospheres that were obtained using PLA have a larger size distribution and higher porosity and an interconnectivity of 99.7%. Loose apatite particles were observed on the surface of macrospheres prepared with alginate and CH by means of soaking into a simulated body fluid (SBF) for 7 days. A dense apatite layer was formed on the biocomposite macrospheres’ surface produced with PLA, which served to protect PLA from degradation. In vitro investigations demonstrated that biocomposite macrospheres had minimal cytotoxic effects on a human osteosarcoma cell line (SaOS-2 cells). However, the accelerated degradation of PLA due to the degradation of bioactive glass may account for the observed decrease in SaOS-2 cells viability. Among the biocomposite macrospheres, those composed of PLA exhibited the most promising characteristics for their potential use as fillers in bone tissue repair applications.Item Development and characterization of ceramic-polymeric hybrid scaffolds for bone regeneration: incorporating of bioactive glass BG-58S into PDLLA matrix(Taylor & Francis) Aguiar, Veronica Cristina Pêgo Fiebig; Bezerra, Rayssa do Nascimento; Santos, Kennedy Wallace dos; Gonçalves, Isabela dos Santos; Costa, Karen Julie Santos Grancianinov; Lauda, Diogo Ponte; Campos, Tiago Moreira Bastos; Prado, Renata Falchete do; Vasconcellos, Luana Marotta Reis de; Oliveira, Ivone Regina deIn recent years, there has been a notable surge of interest in hybrid materials within the biomedical field, particularly for applications in bone repair and regeneration. Ceramic-polymeric hybrid scaffolds have shown promising outcomes. This study aimed to synthesize bioactive glass (BG-58S) for integration into a bioresorbable poly- meric matrix based on PDLLA, aiming to create a bioactive scaffold featuring stable pH levels. The synthesis involved a thermally induced phase separation process followed by lyophilization to ensure an appropriate porous structure. BG-58S characterization revealed vitreous, bioactive, and mesoporous structural properties. The scaffolds were analyzed for morphology, interconnectivity, chemical groups, porosity and pore size distribution, zeta potential, pH, in vitro degradation, as well as cell viability tests, total protein content and mineralization nodule production. The PDLLA scaffold displayed a homogeneous morphology with interconnected mac- ropores, while the hybrid scaffold exhibited a heterogeneous mor- phology with smaller diameter pores due to BG-58S filling. The hybrid scaffold also demonstrated a pH buffering effect on the polymer surface. In addition to structural characteristics, degrada- tion tests indicated that by incorporating BG-58S modified the acidic degradation of the polymer, allowing for increased total pro- tein production and the formation of mineralization nodules, indi- cating a positive influence on cell culture.Item Desenvolvimento de um Creme de Ibuprofeno com Auxílio de Ferramentas de Quality By Design(2023) Ramos, Bruno S.; Baptista, Mayara P.; Oliveira, Ivone Regina deItem Aparato de biomanufatura aditiva, em processo de deposição de hidrogéis tixotrópicos em camadas tridimensionais(2024) Cardoso, Gustavo Luiz Bueno; Oliveira, Ivone Regina de; Ortega, Fernando dos Santos; Nono, Daniel AlessanderItem Estudo e otimização da produção de Vidro Bioativo (BG) por fusão(2022) Santos, Kennedy Wallace dos; Costa, Karen Julie Santos Grancianinov; Lauda, Diogo Ponte; Oliveira, Ivone Regina deItem RLT-016-24 Desenvolvimento da prototipagem de aparato de bioimpressão 3D em duas seringas adaptado para acoplagem em impressora 3D FDM tradicional de modelo Ender 3 V1(2024) Cardoso, Gustavo Luiz Bueno; Ortega, Fernando dos Santos; Oliveira, Ivone Regina de; Nono, Daniel AlessanderItem Eletrodeposição de Polipirrol em Liga de Alumínio 2024: Avaliação da Influência da Corrente de Deposição(2023) Santos, Diogo Monteiro Leite dos; Oliveira, Ivone Regina de; Liu, Yao ChoItem BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor(Springer Nature Link) Grancianinov, Karen Julie Santos; Santos, Kennedy dos; Gonçalves, Isabela; Donda, Giovanni Moreira; Lauda, Diogo Ponte; Amaral, Suelen; Souza, Amanda; Vasconcellos, Luana de; Oliveira, Ivone Regina dePurpose Bioactive glass (BG) spheres with uniform shape and specific size variation are allowed to be packed into a 3D arrangement, which results in an open porosity that improves bone growth. Methods BG-58S macrospheres were produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursors (TEP or phosphoric acid-AF). Macrospheres (MAF-1 M, MAF-2 M, MTEP-1 M, and MTEP-2 M) were characterized as to surface morphology and size, theoretical density, and specific surface area/pore size distribution. In vitro bioactivity was evaluated in simulated body fluid (SBF). In vitro tests were conducted (for MAF-2 M and MTEP-2 M) as cell viability, total protein content, determination of alkaline phosphatase, cell adhesion by means of SEM, and mineralization nodules formation compared to commercial product (BG-45S5). Biological performance was verified through histological and histomorphometric analyses around the samples: BG-45S5, MTEP-2 M, and control (clot). Results All physicochemical characterizations demonstrated favorable macrospheres for application in bone grafting. MTEP-2 M and MAF-2 M showed higher cell viability and total protein content when compared to BG-45S5 with a statisti- cal difference (p < 0.05); however, no statistical difference was detected among the groups regarding the determination of alkaline phosphatase (p > 0.05). Cells adhered to the surface were observed for all samples as well as nodules of minerali- zation. The results referring to in vivo biological assays showed no statistical difference between the experimental groups MTEP-2 M, BV45S5, and clot control in the two periods evaluated (p > 0.05). Conclusion The method used in this study was able to prepare macrosphere bioglass, and this material seems to be a promis- ing biomaterial to improve bone tissue regeneration.Item Substituição de areia por resíduo de vidro em argamassa para assentamento: uma alternativa para mitigar os recursos naturais(2021) Botelho, Kátia Bittencourt; Gonçalves, Érika Peterson; Oliveira, Ivone Regina deItem Produção In Situ de Hexaluminato de Cálcio Microporoso por Moldagem Direta(2023) Leite, Vitória Marques Cesar; Oliveira, Ivone Regina de
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