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Item Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications(SciELO) Barbosa, Ana Margarida; Santos, Kennedy Wallace dos; Gonçalves, Irene S.; Leite, Priscila Maria Sarmeiro Corrêa Marciano; Martorano, Antonio Secco; Grisote, Gabriela; Raucci, Larissa Moreira Spinola de Castro; Oliveira, Paulo Tambasco de; Raniero, Leandro José; Oliveira, Ivone Regina deIn this work blends based on calcium aluminate cement (CAC) containing bioactive glass (BG) (5, 7.5 and 10 wt%) and strontium oxide (1 wt%) were produced aiming improve their bioactivity and the capacity to stimulate the bone regeneration. In the first part, the blends containing only BG were characterized as theoretical density, microhardness, uniaxial cold crush strength after SBF and apparent porosity and pore size distribution before and after SBF treatment. In the second part, bioactivity and cell culture tests were also conducted in the blends containing BG and strontium oxide. The addition of 7.5 wt% of BG in homogeneous calcium aluminate cement (CH) improved its mechanical properties as microhardness and uniaxial cold crushing strength. The blends were more bioactive due to the presence of a highly soluble amorphous phase as confirmed by means of SEM/EDX mainly for 7.5 wt% BG without and with Sr from 1 day in SBF. FTIR analyses indicated the formation the apatite-like phase by means of increase of intensity of the PO43- peaks after SBF treatment. All blends allowed the development of the osteoblastic phenotype and the formation of mineralized matrix increased due to the inclusion of BG and Sr promoting the osteogenesis process.Item Calcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies(Springer Nature) Gonçalves, Isabela dos Santos; Donda, Giovanni Moreira; Oliveira Filho, Hugo Gutemberg Patino de; Fernandes, Marina Santos; Barbosa, Ana Maria; Raniero, Leandro José; Vasconcellos, Luana Marotta Reis de; Oliveira, Ivone Regina deHomogeneous calcium aluminate cement–based (CH) materials hold potential as biomaterials, while bioactive glass (BG-58S) is a promising bone regeneration material with excellent bioactivity. Strontium, known for stimulating bone tissue regeneration, was incorporated into CH-BG-58S blends to enhance bioactivity, osteogenesis, and bone tissue repair. Methods Blends with only BG-58S were evaluated for viscosity, injectability, and workability. In vitro tests were performed using MG63 cells and in vivo tests utilized blends CH-7.5BG-58S and CH-7.5BG-58S/Sr to fill monocortical critical bone defects. Bactericidal capacity against Escherichia coli and Staphylococcus aureus was also evaluated. The addition of BG to CH increased viscosity, decreased injectability, and improved workability. Results All blends were non-cytotoxic, and CH-7.5BG-58S and CH-10BG-58S blends exhibited bactericidal capacity against E. coli. Osteogenic activity, confirmed by mineralization nodule formation, was observed in all blends. Histomorphometric and histological analyses revealed bone neoformation, with emphasis on SrO-containing groups, but without statistical significance among groups (p > 0.05). Conclusion This research highlights the potential of CH-BG-58S blends, particularly those with strontium, as bioactive materials for bone tissue engineering.