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Item Curcumin-coated iron oxide nanoparticles for photodynamic therapy of breast cancer(Springer Nature Link) Ferreira, Virginia Rezende; Ventura, Aveline; Candido, Marcela Aparecida; Ferreira-Strixino, Juliana; Raniero, Leandro JoséBreast cancer is the deadliest cancer among women and its treatment using traditional methods leads the patient to experience adverse effects. However, photodynamic therapy (PDT) is a non-invasive therapy modality that works through a photosensi- tizing agent, which treating activated by a suitable light source, releases reactive oxygen species capable of treating cancer. Furthermore, recent research indicates that combining PDT and nanoparticles can enhance therapeutic effects. In this way, the synthesis of IONPs (iron oxide nanoparticles) was carried out, and their subsequent coating was done with curcumin (IONPs@curcumin) so that they could act as therapeutic agents against breast cancer. Curcumin solubility tests were carried out to achieve the best results, with ethanol as a solvent, in different concentrations of ethanolic curcumin solution, with the optimal outcome observed at a concentration of 1 mM. Subsequently, the stability analysis was conducted by adjusting the pH of the medium, revealing that at pH 10, the IONPs@curcumin exhibited the best stability and dispersion conditions. Then, cytotoxicity tests of IONPs@curcumin were carried out on the MDA-MB-468 triple-negative breast cancer cell line, under experimental conditions without irradiation and subjected to PDT. The results revealed a viability greater than 70%, as it did not exhibit cytotoxicity for cells in the dark. After 1 h of incubation, the PDT associated with IONPs@curcumin showed 32% of cell viability at a concentration of 30 mg/mL.Item Robotic rehabilitation in clinical complications after breast cancer: exoskeleton of upper limbs(Universidade de São Paulo) Mendes, Izabela dos Santos; Oliveira, Fabio Henrique Monteiro; Souza, Gabriela Aparecida de; Sene, Thaisa Prado; Lima, Fernanda Pupio Silva; Andrade, Adriano de Oliveira; Lima, Mario OliveiraBackground: Breast cancer promotes several physical and functional changes. Innovative tech- niques of physiotherapeutic treatment, such as robotic rehabilitation may contribute to the pre- vention or treatment of these complications. Here we aim to evaluate the effects of robotic re- habilitation on clinical complications secondary to breast cancer. Methods: This is a longitudinal clinical study consisting of 26 subjects divided into the following groups: 13 patients (women after breast cancer - G1, Robotic Rehabilitation Group) and 13 healthy women who did not undergo surgery due to breast cancer and constituted the GC (Control Group) to obtain data from elec- tromyography and dynamometry. Ten consecutive therapeutic sessions were performed. The fol- lowing parameters were evaluated in three sessions (session 1 - S1, session 5 - S5 and session 10 - S10): scapular and manual force, myoelectric activity, pain, range of motion, lymphedema and quality of life. Results: Pain threshold attenuation was obtained by comparing S5 with S10 (p = 0.002) and at the end of treatment (p = 0.01); lymphedema reduction after 10 sessions (p = 0.04); increase of abduction ROM when comparing S1 with S10 (p = 0.05); flexion (p = 0.002) in S1 in relation to S10 and shoulder extension (p = 0.05) in S5. Regarding the electromyographic analysis, there were increases in scapular and manual force of the GC versus G1, and changes in variables estimated from the collected signals, especially the increase in signal amplitude for the MAV, PEAK and RMS characteristics of the brachial biceps muscles, anterior and middle del- toid when comparing S1 versus S10. Before the evaluation using the dynamometer, the healthy women presented increase of scapular and manual force in relation to the volunteers after breast cancer. Conclusion: The use of robotic therapy was significantly efficient for pain attenuation, lymphedema, increase range of motion, increased recruitment of muscle fibers and improvement of muscle synergism, which contributed to the improvement of the quality of life.