Programa de Pós-Graduação em Engenharia Biomédica

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Chemical constituents and cytotoxic activity of Eugenia involucrata DC. infusion
(Concilium) Barzotto, Ionete Lúcia Milani; Oliveira, Simone Maria Menegatti de; Silva, Newton Soares; Almeida, Rafaela Takako R.; Pilau, Eduardo J.; Delabeneta, Matheus F.; Vieira, Lúcia
In this work, the chemical constituents of the infusion from the leaves of Eugenia involucrata DC. (Myrtaceae) were elucidated using ultra-high-performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC-MS/MS), as well as Fourier transform infrared spectroscopy (FTIR). The toxicity of the infusion was evaluated using the brine shrimp (Artemia salina) lethality test. Nineteen chemical compounds were identified by UHPLC-MS/MS: gallic acid; quinic acid; epicatechin; gallocatechin; (epi)afzelechin-(epi)catechin; quercetin-3-O-rhamnoside (quercitrin); citric acid; tryptophan; aconitic acid; (-)-epicatechin-(4β→8)-(-)-epicatechin (procyanidin B2); rutin; quercetin-3-O-glucoside; naringenin-7-O-glucoside (prunin); coumaric acid; azelaic acid; quercetin; naringenin; kaempferol-3-O-glucoside (astragalin). FTIR analysis revealed bands attributed to phenols and alcohols, alkanes and carboxylic acids, flavonoids and polyphenols, aromatic compounds, and aliphatic amines. According to the results, the infusion of E. involucrata DC. demonstrated atoxicity and contained chemical components that could be useful in the development of new therapeutic or herbal agents.