Programa de Pós-Graduação em Engenharia Biomédica

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https://repositorio.univap.br/handle/123456789/34

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Analysis of Movements in Spinal Cord Hemisection Treatment with Amniotic Membrane – Preclinical Study
(Scientific Research Publishing Inc.) Neves, Marcele Florêncio das; Fonseca, Joyce Lilian Reis da; Carvalho, Paula Cristina Simões de; Pereira, Aline Priscila Campos; Polisel, Evandro Henrique Pintor; Proglhof, Stephanie de Medeiros Passos; Sant ́Anna, Luciana Barros; Lima, Mário Oliveira; Arisawa, Emília Ângela Lo Schiavo
Aims: This study aimed to evaluate the efficacy of Amniotic Membrane application in rats with Spinal Cord Injury induced by transverse hemisection using kinematic analysis and Sciatic Functional Index. Study design: True experimental research design. Place and Duration of Study: Instiuto de Pesquisa e Desenvolvimento (IP&D) of Universidade do Vale do Paraíba (UNIVAP), between September 2016 and December 2017. Methodology: Fifteen adult male rats were used, allocated into three equal groups: Control (the spinal cord injury and Amniotic Membrane application were simulated), Lesion (spinal cord injury not treated), Amniotic membrane (spinal cord injury treated by amniotic membrane). All animals underwent surgical procedures. A transverse hemisection was performed in groups Lesion and Amniotic Membrene. A fragment of the biomaterial was applied in group AM covering the hemisection area. Results: Sciatic Functional Index and motion analysis were performed by comparing images taken at pre- and postoperative time at 7, 14, 21, and 28 days. The kinematic analysis showed a significant difference between groups Control and Lesion at 7 days (p = 0.023) and 14 days (p = 0.015), and between groups Lesion and Amniotic Membrane at 14 days (p = 0.039), comparing the postoperative periods. The Sciatic Functional Index revealed significant differences between Groups Control and Lesion at 7 (p = -0.002), 14 (p = 0.003), and 21 days (p = 0.009), between Groups Control and Amniotic Membrane at 7 (p = 0.014), 14 (p = 0.007), and 28 days (p = 0; 013), and between Groups Lesion and Amniotic Membrane only at 14 days (p = 0.039). Conclusion: Application of amniotic membrane in spinal cord hemisection in rats induced gait recovery and improvement in SFI compared to the untreated group.
Evaluation of the effects of photobiomodulation (808 nm) on pain and quality of life of diabetic neuropathy patients
(CDRR Editors) Leal, Milena Valdinéia da Silva; Lima, Mário Oliveira; Costa, Davidson Ribeiro; Nicolau, Renata Amadei; Ribeiro, Luana Aparecida Pilato; Costa, David Ribeiro; Carvallho, Teresa Marly Teles de; Silva, Kelson Nonato Gomes da; Pessoa, Diego Rodrigues; Arisawa, Emília Ângela Lo Schiavo
Diabetic neuropathy (DN) is one of the main complications of diabetes mellitus (DM), responsible for a high morbimortality rate and burdening public health resources. Photobiomodulation has proven to be effective in relieving pain, reducing the inflammation, and improving vascularization. We report an evaluation of the effectiveness of photobiomodulation for the relief of pain and to improve the quality of life in patients with diabetic neuropathy. A total of 30 diabetic volunteers with DN were randomly divided into three groups: control, photobiomodulation (PBM), and placebo (P-PBM). Those in Group control were instructed to take diabetic neuropathy medication for 30 days. The PBM group received laser photobiomodulation treatment with the following protocol: three sessions per week for 30 days, totaling 12 applications (wavelength, 808 nm; energy density, 12 J/cm²). in the of following nerves: tibial medial plantar, own plantar digital, common plantar digital, superficial fibular, deep fibular, sciatic, saphenous, and common fibular. Patients in the P-PBM Group were submitted to the PBM protocol, but with the device switched off. Before and after applying the therapeutic protocols, all volunteers were subjected to pain evaluations. The results showed a statistically significant difference between the groups (p < 0.05). The PBM group confirmed an analgesic effect directly related to the use of the photobiomodulation, whilst the patients in group control and P-PBM, did not present significant results. The study demonstrated that laser photobiomodulation is effective in significantly reducing pain and improving the quality of life of patients with diabetic neuropathy.
Hiperhidrose e síndrome de taquicardia pós-COVID-19
(CDRR Editors) Rebêlo, Veruska Cronemberger Nogueira; Silva, Eva Karoline Rodrigues da; Lemos, Mikaelli Priscila Rosas; Cabral, Patrícia Uchôa Leitão; Carvalho, Ana Flávia Machado de; Feitosa, Maura Cristina Porto; Coelho, Nayana Pinheiro Machado de Freitas; Monteiro, Luana de Moura; Portela, Fabiana Teixeira de Carvalho; Arisawa, Emília Ângela Lo Schiavo
A pandemia causada pelo novo coronavírus SARS-CoV-2, COVID-19, tem impactado o cenário mundial, agravando as taxas de morbidade e mortalidade. Entre os sintomas persistentes da COVID-19, denominada Covid Longa (CL) ou Síndrome Pós Covid (SPC), as manifestações neurológicas assumem importância significativa por sua associação com o agravamento do quadro clínico dos pacientes. Dentre as complicações observadas em pacientes críticos, destaca-se a Hiperatividade Paroxística Simpática (HSP), caracterizada por sintomas súbitos de aumento do tônus simpático. O objetivo desse estudo foi relatar um caso de HSP em paciente portador de hiperidrose e Síndrome de Taquicardia Ortostática Postural (STOP) pós-COVID-19, ao qual foi aplicado protocolo de tratamento composto por laserpuntura e liberação miofascial no ambulatório de um hospital público em Teresina-PI. Para coleta dos dados foram utilizados os instrumentos Depression Anxiety Stress (DASS-21), Mini Exame do Estado Mental (MEEM), Questionário Nórdico de Sintomas Osteomusculares (QNSO), Questionário de Avaliação de Qualidade de Vida (WHOQOL-BREF), Índice de Qualidade de Sono de Pittsburgh (PSQI), Escala Visual Analógica (EVA) e Algometria. Os resultados mostraram redução da taquicardia, hiperidrose, nível de estresse, ansiedade e depressão, diminuição das dores musculares, aumento do Limiar de Percepção Dolorosa (LDP) com consequente redução do afastamento das atividades rotineiras, impactando na melhora da qualidade de vida geral e do sono. Conclui-se que o tratamento por meio de laserpuntura e liberação miofascial foi eficaz nos sintomas da HSP e consequente melhoria da qualidade de vida da paciente.

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