Exploring Antioxidant, Antimicrobial and Anti-Inflammatory Effects of Juglans regia and Pfaffia paniculata Extracts: implications for Intestinal Dysbiosis and Colorectal Cancer Risk Associated with Oral Pathogens

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dc.contributor.authorMiranda, Diego Garcia
dc.contributor.authorRamos, Lucas de Paula
dc.contributor.authorAttik, Nina
dc.contributor.authorSilva, Nicole Van Der Heijde Fernandes
dc.contributor.authorCamargo, Pyetra Claro
dc.contributor.authorAraujo, Gabriela Ferraz de
dc.contributor.authorLopes, Nicole Fernanda dos Santos
dc.contributor.authorMarcucci, Maria Cristina
dc.contributor.authorSoares, Cristina Pacheco
dc.contributor.authorGodoi, Bruno Henrique
dc.contributor.authorCaires, Giovanna Arruda
dc.contributor.authorVigerelli, Hugo
dc.contributor.authorCarrouel, Florence
dc.date.accessioned2026-01-12T13:08:52Z
dc.date.available2026-01-12T13:08:52Z
dc.date.issued22025
dc.description.abstractColorectal neoplasms rank as the third most prevalent cancer globally and stand as the second leading cause of cancer-related mortality. Its etiol- ogy is multifaceted, pointing to the role of microorganisms within the human microbiota in its development. Notably, the high prevalence of oral pathogens like Fusobacterium nucleatum and Parvimonas micra is implicated in inducing gut dysbiosis and stimulating the proliferation and metastasis of cancer cells. Therefore, this study aimed to evaluate in vitro the biological effects of extracts from Juglans regia and Pfaffia paniculata. Methods: Phytochemical analysis was carried out by HPLC, and the antioxidant effect was deter- mined by DPPH. Antimicrobial activity was investigated on F. nucleatum and P. micra planktonic and biofilms. Metabolic activity and genotoxicity were performed. Results: J. regia and P. paniculata expressed CE50 37.26 and 1367.57 mcg, respectively. The extracts exhibited a minimum bactericidal concentration of 1.73 and 0.48 mg/mL for J. regia and P. paniculata, respectively. Reduction superiorly 90% of P. micra biofilms. Metabolic activity was varied proportionally to the extract concentration, and no genotoxic effects were ob- served. Conclusions: The J. regia extract has great antioxidant activity and could be used as an alternative in combating pathogens associated with the onset of dysbiosis and tumor progression in colorectal neoplasms. Nevertheless, further studies are needed to validate their clinical applicability.
dc.description.physical17 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.uriCAPES: 88887.891487/2023-00 and 88887.829787/2023-00
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversity of Lyon
dc.identifier.affiliationUniversidade do Estado de São Paulo
dc.identifier.affiliationUniversidade Anhembi Morumbi
dc.identifier.affiliationUniversidade Federal de Alfenas
dc.identifier.affiliationInstituto Butantan
dc.identifier.bibliographicCitationMIRANDA, D. G. et al. Exploring Antioxidant, Antimicrobial and Anti-Inflammatory Effects of Juglans regia and Pfaffia paniculata Extracts: Implications for Intestinal Dysbiosis and Colorectal Cancer Risk Associated with Oral Pathogens. Pharmaceutics, v. 17, n. 6, p. 1-17, 2025. Disponível em: https://www.mdpi.com/1999-4923/17/6/693.
dc.identifier.doi10.3390/pharmaceutics17060693
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1074
dc.language.isoen_US
dc.publisherMDPI
dc.rights.holderPharmaceutics
dc.subject.keywordColorectal neoplasms
dc.subject.keywordDysbiosis
dc.subject.keywordAnaerobic bacteria
dc.subject.keywordWalnut
dc.subject.keywordBrazilian ginseng
dc.subject.keywordAntioxidant
dc.subject.keywordAntimicrobial agents
dc.subject.keywordHerbal medicine
dc.subject.keywordPhenolic compounds
dc.subject.keywordPlant extract
dc.titleExploring Antioxidant, Antimicrobial and Anti-Inflammatory Effects of Juglans regia and Pfaffia paniculata Extracts: implications for Intestinal Dysbiosis and Colorectal Cancer Risk Associated with Oral Pathogens
dc.typeArtigos de Periódicos

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