Analysis of the effects of Photodynamic therapy with Photodithazine on the treatment of 9l/lacZ cells, in vitro study

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dc.contributor.authorVitorio, Gabrielle dos Santos
dc.contributor.authorAlmeida, Rainara Moreno Sanches de
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorFontana, Letícia Corrêa
dc.contributor.authorFerreira-Strixino, Juliana
dc.date.accessioned2025-06-10T18:05:01Z
dc.date.available2025-06-10T18:05:01Z
dc.date.issued22021
dc.description.abstractGliosarcoma is an aggressive brain tumor. Photodynamic Therapy (PDT) is a treatment that can be used for various cancers of the CNS. The aim of this study was to analyze the effects of PDT with Photodithazine (PDZ) in the treatment of gliosarcoma, using 9 L/lacZ cells and serial concentrations of 200 μg/mL to 3.1 μg/mL of PDZ. The samples were divided into two groups: dark and light (10 J/cm2). The PDZ was internalized along all the cytoplasmic extension. Viability tests demonstrated a reduction in viable cells after PDT. The production of ROS was concentration-dependent and PDZ was found in mitochondria and lysosomes, presenting a discrete connection with α-tubulin. However, this structure is likely damaged, evidenced by changes in the morphological analysis. Thus, according to the parameters of this study, PDZ proved to be an interesting PS in PDT for the treatment of gliosarcoma, with the inherent limitations of an in vitro study.
dc.description.physical11 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriFAPESP ( 2018/12274-1, 2018/15302-6 and n ° 2016/12211-4) CAPES (Financing Code 001) FINEP (01.13.0275.00)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationVITORIO, G. S. et al. Analysis of the effects of Photodynamic therapy with Photodithazine on the treatment of 9l/lacZ cells, in vitro study. Photodiagnosis and Photodynamic Therapy, v. 34, p. 1-11, 2021. Disponível em:
dc.identifier.doi10.1016/j.pdpdt.2021.102233
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/990
dc.language.isoen_US
dc.publisherElsevier
dc.rights.holderElsevier
dc.subject.keywordBrain cancer
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordChlorin
dc.subject.keywordConfocal microscopy
dc.titleAnalysis of the effects of Photodynamic therapy with Photodithazine on the treatment of 9l/lacZ cells, in vitro study
dc.typeArtigos de Periódicos

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