Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers

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dc.contributor.authorMartins, Tassia Joi
dc.contributor.authorParisi, Cristina
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorBrambilla, Isabelle de Paula Ribeiro
dc.contributor.authorMalanga, Milo
dc.contributor.authorFerreira-Strixino, Juliana
dc.contributor.authorSortino, Salvatore
dc.date.accessioned2026-01-15T17:27:41Z
dc.date.available2026-01-15T17:27:41Z
dc.date.issued22024
dc.description.abstractA hydrophobic nitric oxide (NO) photodonor integrating both nitroso and nitro functionalities within its chromophoric skeleton has been synthesized. Excitation of this compound with blue light triggers the release of two NO molecules from the nitroso and the nitro functionalities via a stepwise mechanism. Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest. Antibacterial tests carried out with methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii demonstrate an effective antibacterial activity exclusively under light activation and point out a differentiated role of the polymeric nanocarriers in determining the outcome of the antibacterial photodynamic action.
dc.description.physical7 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.uriFAPESP - 2022/10251-0
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversity of Catania
dc.identifier.affiliationCarboHyde
dc.identifier.bibliographicCitationMARTINS, T. J. et al. Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers. ACS Medicinal Chemistry Letters, v. 15, n. 6, p. 857-863, 2024. Disponível em: https://pubs.acs.org/doi/10.1021/acsmedchemlett.4c00061.
dc.identifier.doi10.1021/acsmedchemlett.4c00061
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1095
dc.language.isoen_US
dc.publisherACS Publications
dc.rights.holderACS Medicinal Chemistry Letters
dc.subject.keywordNitric oxide
dc.subject.keywordCyclodextrin polymers
dc.subject.keywordAntibacterial
dc.titleStepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers
dc.typeArtigos de Periódicos

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