Comparison of the Photodynamic Effect of Two Chlorins, Photodithazine and Fotoenticine, in Gliosarcoma Cells

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dc.contributor.authorFontana, Letícia Corrêa
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorMagalhães, Jéssica Aparecida
dc.contributor.authorTada, Dayane Batista
dc.contributor.authorAlmeida, Rainara Moreno Sanches de
dc.contributor.authorPacheco-Soares, Cristina
dc.contributor.authorFerreira-Strixino, Juliana
dc.date.accessioned2025-03-27T18:27:11Z
dc.date.available2025-03-27T18:27:11Z
dc.date.issued22022-02-25
dc.description.abstractThe treatment and prognosis of cancers of the nervous system remain unfavorable to the patient, which makes it necessary to study alternative therapies as primary or adjuvant treatments to existing methods. Photodynamic Therapy (PDT) is a method that consists of combining a photosensitizer (PS), a light source at the appropriate wavelength, and molecular oxygen, forming reactive oxygen species (ROS), leading to death in the target cell. The objective of this work was to compare the effects of PDT with two chlorins, Photodithazine (PDZ) and Fotoenticine (FTC), in 9L/lacZ gliosarcoma cell lines. Both chlorins, together with an LED device at 660 nm with a fluence of 10 J/cm2 , were included in the study. It was observed that the response to therapy depends on the concentration and type of PS used. In addition, PDZ showed a higher quantum yield of singlet oxygen generation than FTC.
dc.description.physical17 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriFAPESP: number: 2016/20022–7 and 2016/12211–4
dc.format.mimetypepdf
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Federal de São Paulo
dc.identifier.affiliationUniversidade Federal de São Paulo
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationFONTANA, L. C. et al. Comparison of the Photodynamic Effect of Two Chlorins, Photodithazine and Fotoenticine, in Gliosarcoma Cells. Photochem, [S. l.], v. 2, n. 1, p. 165–180, 25 fev. 2022. Disponível em: https://www.mdpi.com/2673-7256/2/1/13.
dc.identifier.doi10.3390/photochem2010013
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/778
dc.language.isoen_US
dc.publisherMDPI
dc.rights.holderMDPI
dc.rights.holderLetícia Corrêa Fontana
dc.rights.holderJuliana Guerra Pinto
dc.rights.holderJéssica Aparecida Magalhães
dc.rights.holderDayane Batista Tada
dc.rights.holderRainara Moreno Sanches de Almeida
dc.rights.holderCristina Pacheco-Soares
dc.rights.holderJuliana Ferreira-Strixino
dc.subject.keywordBrain tumor
dc.subject.keywordPhotosensitizer
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordQuantum yield
dc.titleComparison of the Photodynamic Effect of Two Chlorins, Photodithazine and Fotoenticine, in Gliosarcoma Cells
dc.typeArtigos de Periódicos

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