Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries

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dc.contributor.authorTerra-Garcia, Maíra
dc.contributor.authorSouza, Cheyenne Marçal de
dc.contributor.authorGonçalves, Nathalia Maria Ferreira
dc.contributor.authorPereira, André Henrique Correia
dc.contributor.authorBarros, Patrícia Pimentel de
dc.contributor.authorBorges, Alessandra Bühler
dc.contributor.authorMiyakawa, Walter
dc.contributor.authorFerreira-Strixino, Juliana
dc.contributor.authorJunqueira, Juliana Campos
dc.date.accessioned2025-06-10T18:33:54Z
dc.date.available2025-06-10T18:33:54Z
dc.date.issued22021
dc.description.abstractPhotodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine (FTC) derived from chlorin e6. The objective of this study was to investigate the photodynamic effects of FTC against several clinical strains of S. mutans. Clinical isolates were obtained from patients with active carious lesions, identified by molecular analysis and subjected to PDT using laser irradiation (660 nm and 39.5 J/cm2) in planktonic and biofilm stages. We identified 11 S. mutans strains from cervical, occlusal and proximal caries. PDT mediated by FTC has totally eliminated the S. mutans cells in planktonic growth for all analyzed strains. In biofilms, PDT with FTC reached statistically significant reductions compared with the non-treated control group, at 5.4, 5.5 and 6.5 Log10 (CFU/mL), respectively, for the strains from proximal, occlusal and cervical caries. The scanning electron microscopy evaluations confirmed that PDT mediated by FTC was able to disaggregate and kill the S. mutans cells adhered to enamel surface, suggesting its potential to disinfect the dental tissues.
dc.description.physical8 p.
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriPhotodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine (FTC) derived from chlorin e6. The objective of this study was to investigate the photodynamic effects of FTC against several clinical strains of S. mutans. Clinical isolates were obtained from patients with active carious lesions, identified by molecular analysis and subjected to PDT using laser irradiation (660 nm and 39.5 J/cm2) in planktonic and biofilm stages. We identified 11 S. mutans strains from cervical, occlusal and proximal caries. PDT mediated by FTC has totally eliminated the S. mutans cells in planktonic growth for all analyzed strains. In biofilms, PDT with FTC reached statistically significant reductions compared with the non-treated control group, at 5.4, 5.5 and 6.5 Log10 (CFU/mL), respectively, for the strains from proximal, occlusal and cervical caries. The scanning electron microscopy evaluations confirmed that PDT mediated by FTC was able to disaggregate and kill the S. mutans cells adhered to enamel surface, suggesting its potential to disinfect the dental tissues.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Estado de São Paulo
dc.identifier.affiliationInstituto de Estudos Avançados
dc.identifier.bibliographicCitationTERRA-GARCIA, Maíra et al. Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries. Photodiagnosis and Photodynamic Therapy, v. 34, p. 1-8, 2021. Disponível em:
dc.identifier.doi10.1016/j.pdpdt.2021.102303
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/991
dc.language.isoen_US
dc.publisherElsevier
dc.rights.holderPhotodiagnosis and Photodynamic Therapy
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordStreptococcus mutans
dc.subject.keywordDental caries
dc.subject.keywordFotoenticine
dc.titleAntimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries
dc.typeArtigos de Periódicos

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