Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line

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dc.contributor.authorFontana, Letícia Corrêa
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorVitorio, Gabrielle dos Santos
dc.contributor.authorFerreira, Isabelle
dc.contributor.authorPacheco-Soares, Cristina
dc.contributor.authorMamone, Leandro
dc.contributor.authorFerreira‐Strixino, Juliana
dc.date.accessioned2025-04-02T16:53:27Z
dc.date.available2025-04-02T16:53:27Z
dc.date.issued22022-03
dc.description.abstractPhotodynamic Therapy (PDT) is an oncologic treatment, producing reactive oxygen species (ROS) to induce the death of cancer cells. This study aimed to evaluate the action of PDT on gliosarcoma cells, using protoporphyrin IX as PS by incubation with the precursor aminolevulinic acid (ALA). An LED device was used with a light dose of 10 J/cm². The success of the therapy proved to be dependent on the concentration of ALA, and an incubation time of 4 h required for an effective response. Cell death was prevalent due to necrosis when assessed 18 h post-PDT. ALA proved to be an option to PDT in cells of the 9 L/lacZ, with the protocol tested.
dc.description.physical11 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriFAPESP: number: 2016/20022–7 and 2016/12244–1. FAPESP/CEPOF: 2013/07276–1 FINEP: Convenio 01.13.0275.00 CAPES: Financing Code 001.
dc.format.mimetypepdf
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversity of Buenos Aires
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationFONTANA, L. C. et al. Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line. Photodiagnosis and Photodynamic Therapy, [S. l.], v. 37, p. 102669, mar. 2022. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S1572100021004865.
dc.identifier.doi10.1016/j.pdpdt.2021.102669
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/796
dc.language.isoen_US
dc.publisherElsevier B.V.
dc.rights.holderElsevier B.V.
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordGliosarcoma
dc.subject.keywordBrain cancer
dc.subject.keyword5-ALA
dc.subject.keywordAminolevulinic acid
dc.titlePhotodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line
dc.typeArtigos de Periódicos

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