Chemical and cellular characterization of SPIONs stabilized with sodium citrate

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dc.contributor.authorCândido, Marcela Aparecida
dc.contributor.authorJesus, Viviane Paula dos Santos
dc.contributor.authorVieira, Paula Fonseca Antunes
dc.contributor.authorCampos, Andrea
dc.contributor.authorRaniero, Leandro José
dc.date.accessioned2025-08-21T19:43:20Z
dc.date.available2025-08-21T19:43:20Z
dc.date.issued22025
dc.description.abstractIntroduction Iron oxide nanoparticles (IONPs) represent a class of magnetic and biocompatible nanomaterials that have been widely used in research and medical applications, such as hyperthermia studies, as contrast agents for magnetic reso- nance imaging, biosensors, among others. Some studies have already evaluated several formulations containing IONPs in preclinical and clinical trials under the approval of the US Federal Agency. Methods IONPs were obtained by chemical coprecipitation, in which aqueous solutions of precursors containing iron (Fe3+) and ferrous (Fe2+) ions are alkalized under control of temperature and pH. The stabilization process of iron oxide nano- particles was done by sodium citrate and characterize the hydrodynamic diameter and the zeta potential by dynamic light scattering (DLS), the morphology and the diameter by transmission electron microscopy (TEM), crystal structure by X-ray diffraction (XRD), chemical composition by Fourier transform infrared spectroscopy (FT-IR), and magnetic properties by vibrating sample magnetometer (VSM). Results The DLS, MET, and FT-IR analyses confirmed that the superparamagnetic IONPs (SPIONs) syntheses had diameters smaller than 100 nm and were stabilized since the vibrational bands were present both in the sodium citrate and SPIONs spectra. IONPs exhibit superparamagnetic behavior due to the magnetic properties of the crystalline phase. Finally, pho- tothermal therapy study was carried out to determine the cell viability of MDA-MB-468 cell line after the application of SPIONs at concentrations of 0.5, 10, and 75 μg mL−1 by flow cytometry. Conclusion IONPs were synthesized in the nanometric range, and photothermal therapy shows promising results for triple- negative breast cancer treatment.
dc.description.physical10 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.uriFAPESP (2019/26353–3) CNPq (302158/2022–7)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationFrance Aix-Marseille University
dc.identifier.bibliographicCitationCANDIDO, M. A. Chemical and cellular characterization of SPIONs stabilized with sodium citrate. Research on Biomedical Engineering, v. 41, n. 1, p. 1-10, 2025. Disponível em: 10.1007/s42600-024-00384-1.
dc.identifier.doi10.1007/s42600-024-00384-1
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1032
dc.language.isoen_US
dc.publisherSpringer Nature Link
dc.rights.holderResearch on Biomedical Engineering
dc.subject.keywordIron oxide nanoparticle
dc.subject.keywordChemical coprecipitation method
dc.subject.keywordSuperparamagnetism
dc.subject.keywordFlow cytometry
dc.titleChemical and cellular characterization of SPIONs stabilized with sodium citrate
dc.typeArtigos de Periódicos

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