A new approach in bone tissue regeneration: in vivo study of the impact of calcium aluminate cement scaffolds incorporated with mesenchymal cells

Página do item simplificado
dc.contributor.authorBronze, Carla da Silveira e Oliveira
dc.contributor.authorGrisante, Letícia Adrielly Dias
dc.contributor.authorAraújo, Juliani Caroline Ribeiro de
dc.contributor.authorGuardia, Rafaella Souza
dc.contributor.authorVicuna, Iranel de las Nievez González
dc.contributor.authorOliveira, Ivone Regina de
dc.contributor.authorVasconcellos, Luana Marotta Reis de
dc.date.accessioned2026-01-13T19:35:59Z
dc.date.available2026-01-13T19:35:59Z
dc.date.issued22025
dc.description.abstractObjective: The objective of this study was to evaluate the bone regeneration potential of CAC-based scaffolds, with or without mesenchymal stem cells (MSC), in bone defects created in rat femurs. Material and Methods: Forty-eight CAC scaffolds and their blends of tricalcium phosphate (TCP), zinc oxide (ZNO), and zirconia (ZIRC) were produced, with half of these incorporated with MSC. Twenty-three Wistar rats were used, with 3 for MSC isolation and 20 for creating bone defects in both femurs. Five animals were assigned to each group, and during the defect surgery and material insertion, the animals received MSC-incorporated scaffolds on the left side and non-incorporated scaffolds on the right side, with the same type of material used in each animal to avoid different systemic effects (n=5); they were euthanized 21 days after the surgical procedure. Results: In the scanning electron microscopy analysis of the scaffolds, structures with open and interconnected pores, as well as cell adhesion, were observed in all groups. In the histological analysis, all groups showed newly formed bone trabeculae interspersed with bone marrow cells and connective tissue. Conclusion: In the histomorphometry, for the scaffolds not incorporated with MSC, the ZIRC group showed greater bone formation, and in the MSC- incorporated scaffolds, the TCP group demonstrated better results, both exhibiting a statistically significant difference from the other groups (p<0.05).
dc.description.physical14 p.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.bibliographicCitationBRONZE, C. S. et al. A new approach in bone tissue regeneration: in vivo study of the impact of calcium aluminate cement scaffolds incorporated with mesenchymal cells. Brazilian Dental Science, v. 8, n. 1, p. 1-14, 2025. Disponível em: https://ojs.ict.unesp.br/index.php/cob/article/view/4296.
dc.identifier.doi10.4322/bds.2025.e4296
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1084
dc.language.isoen_US
dc.publisherUniversidade Estadual Paulista
dc.rights.holderBrazilian Dental Science
dc.subject.keywordBiocompatible materials
dc.subject.keywordBone cements
dc.subject.keywordBone regeneration
dc.subject.keywordBone tissue
dc.subject.keywordMesenchymal stem cells
dc.titleA new approach in bone tissue regeneration: in vivo study of the impact of calcium aluminate cement scaffolds incorporated with mesenchymal cells
dc.title.alternativeUma nova abordagem na regeneração do tecido ósseo: estudo in vivo do impacto de scaffolds de cimento de aluminato de cálcio incorporado com células mesenquimais
dc.typeArtigos de Periódicos

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
A new approach in bone tissue regeneration.pdf
Tamanho:
3.15 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

Produção acadêmica-PPGEB