(PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti- biofilm activities

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dc.contributor.authorSilva, Bruna Marques da
dc.contributor.authorBraga, Marília Toledo
dc.contributor.authorPassos, Juliene Cristina da Silva
dc.contributor.authorCarvalho, Moisés Lopes
dc.contributor.authorRosseti, Isabela Bueno
dc.contributor.authorAmorim, Laís Mayara Machado de
dc.contributor.authorRocha, João Batista Teixeira da
dc.contributor.authorSilva, Carlos Alberto
dc.contributor.authorCosta, Maricilia Silva
dc.date.accessioned2025-06-13T16:32:52Z
dc.date.available2025-06-13T16:32:52Z
dc.date.issued22021
dc.description.abstractAdhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by Candida albicans. The ability of (PhSe)2 and (pCl-PhSe)2, two synthetic organic selenium (organochalcogen) compounds, to act on C. albicans virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was ana- lyzed. Both organochalcogen compounds inhibited C. albicans adhesion to HeLa cells, depend- ent on compound concentrations. (PhSe)2 (at 20 mM; p 1⁄4 0.0012) was significantly more effective than (pCl-PhSe)2 (at 20 mM; p 1⁄4 0.0183) compared with the control. (PhSe)2 inhibited biofilm for- mation and decreased biofilm viability in both early and mature biofilms more efficiently than (pCl-PhSe)2. Overall, the organochalcogen compounds, especially (PhSe)2, were demonstrated to be effective antifungal drugs against C. albicans virulence factors related to epithelial cell surface adhesion and the formation and viability of biofilms.
dc.description.physical12 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriCAPES – Finance Code 001
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Federal de Santa Maria
dc.identifier.affiliationUniversidade Federal do ABC
dc.identifier.bibliographicCitationSILVA, B. M. et al. (PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities. Biofouling, v. 37, n. 2, p. 235-245, 2021. Disponível em: https://www.tandfonline.com/doi/full/10.1080/08927014.2021.1897110.
dc.identifier.doi10.1080/08927014.2021.1897110
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1006
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.rights.holderBiofouling
dc.subject.keywordCandida albicans
dc.subject.keywordOrganochalcogen
dc.subject.keywordCompounds
dc.subject.keywordBiofilm
dc.subject.keywordAntifungal therapy
dc.subject.keywordCell adhesion
dc.subject.keywordHeLa cells
dc.title(PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti- biofilm activities
dc.typeArtigos de Periódicos

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