Synthesis and Characterization of Stealth Liposomes for Acmella oleracea L. Encapsulation

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dc.contributor.authorMelo, Josué David Gimenez de
dc.contributor.authorTosato, Maira Gaspar
dc.contributor.authorSlapnik, Ana Maria do Espírito Santo
dc.contributor.authorOliveira, Ivone Regina de
dc.contributor.authorRaniero, Leandro José
dc.date.accessioned2026-01-14T19:24:38Z
dc.date.available2026-01-14T19:24:38Z
dc.date.issued22025
dc.description.abstractLiposomes have been proven to be an excellent tool for drug delivery and cosmetic use, minimizing side effects, for example, allergic reactions, making them more precise and effective in delivering active ingredients. This study aims to develop and investigate the composition of the liposome and the possible interactions between its constituents: lipoid S75, cholesterol, and polyvinylpyrrolidone. Formulations and laboratory analyses were conducted to characterize and maximize the mechanical strength and stability of the liposomes, also assessing the viability of encapsulating medicinal herbs. The thin-film hydration method was used in the formulation of the liposomes. For characterization, instrumental analysis techniques such as mid infrared spectroscopy, differential scanning calorimetry, dynamic light scattering, field emission scanning electron microscopy, and chemometrics for data optimization were employed. The results show spherical particles at the nanometric scale and good integration between cholesterol, polyvinylpyrrolidone, and the lipid matrix, providing greater stability and strength to the liposomal matrix. Therefore, the formulations developed in this study demonstrated reliability in the control of components as well as the encapsulation of the medicinal herb jambu, enabling the potential for new developments in pharmaceuticals for future therapeutic and cosmetic applications.
dc.description.physical6 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriCNPq: 152322/2022-1; 302158/2022-7 FAPESP: 2022/07411-5
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Federal de São Paulo
dc.identifier.bibliographicCitationMELO, J. D. G. et al. Synthesis and Characterization of Stealth Liposomes for Acmella oleracea L. Encapsulation. ChemistrySelect, v. 10, n. 26, p. 1-6, 2025. Disponível em: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202502248.
dc.identifier.doi10.1002/slct.202502248
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1090
dc.language.isoen_US
dc.publisherWiley
dc.rights.holderChemistrySelect
dc.subject.keywordAcmella oleracea L
dc.subject.keywordLipoid S75
dc.subject.keywordLiposome
dc.titleSynthesis and Characterization of Stealth Liposomes for Acmella oleracea L. Encapsulation
dc.typeArtigos de Periódicos

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