Photobiomodulation and amniotic membrane for treat tendon injury in rats

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dc.contributor.authorNicodemo, Mariana de Castro
dc.contributor.authorArisawa, Emilia Angela Lo Schiavo
dc.contributor.authorSant’Anna, Luciana Barros
dc.contributor.authorMartins, Rodrigo Álvaro Brandão Lopes
dc.date.accessioned2026-01-13T14:32:15Z
dc.date.available2026-01-13T14:32:15Z
dc.date.issued22024
dc.description.abstractTendons, complex fibrous structures, are subjected to great tensions, which can give rise to the so-called tendinopathies. This study aimed to evaluate photobiomodulation and human Amniotic Membrane applied as single or combined therapies to treat induced Achilles tendon lesions. Seventy-five rats were divided into five groups (n=15): C- control Sham surgery; I- tendon injury; LA- tendon injury treated with photobiomodulation; AM- tendon injury treated with Amniotic Membrane; LAM- tendon injury + photobiomodulation and Amniotic Membrane, subdivided into three groups (n=5) with analysis at 3, 7, and 14 days. The tendon injuries were made with a 20 g weight released from a mini guillotine onto the ankle in dorsiflexion. AM and LAM groups received an Amniotic Membrane fragment while LA and LAM groups received transcutaneous photobiomodulation, using a 660 nm wavelength laser. The inflammatory cells showed statistical differences between groups C and I (p<0.05), I and AM (p<0.01), I and LA (p<0.05), and I and LAM (p<0.01). Both photobiomodulation and Amniotic Membrane were shown to enhance tendon repair, and the association of photobiomodulation plus Amniotic Membrane was the most effective treatment. We conclude that the association of photobiomodulation plus Amniotic Membrane was effective in accelerating and improving the tendon regeneration process.
dc.description.physical12 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.uriFAPESP: 13/07276-1
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationNICODEMO, M. C. et al. Photobiomodulation and amniotic membrane for treat tendon injury in rats. Anais da Academia Brasileira de Ciências, v. 96, supl. 1, p. 1-12, 2024. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000300704&tlng=en.
dc.identifier.doi10.1590/0001-3765202420231139
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1080
dc.language.isoen_US
dc.publisherAcademia Brasileira de Ciências
dc.rights.holderAnais da Academia Brasileira de Ciências
dc.subject.keywordAchilles Tendon
dc.subject.keywordAmniotic membrane
dc.subject.keywordHealing
dc.subject.keywordRegeneration
dc.titlePhotobiomodulation and amniotic membrane for treat tendon injury in rats
dc.typeArtigos de Periódicos

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