BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor

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dc.contributor.authorGrancianinov, Karen Julie Santos
dc.contributor.authorSantos, Kennedy dos
dc.contributor.authorGonçalves, Isabela
dc.contributor.authorDonda, Giovanni Moreira
dc.contributor.authorLauda, Diogo Ponte
dc.contributor.authorAmaral, Suelen
dc.contributor.authorSouza, Amanda
dc.contributor.authorVasconcellos, Luana de
dc.contributor.authorOliveira, Ivone Regina de
dc.date.accessioned2025-03-11T14:32:01Z
dc.date.available2025-03-11T14:29:40Z
dc.date.available2025-03-11T14:32:01Z
dc.date.issued22024
dc.description.abstractPurpose Bioactive glass (BG) spheres with uniform shape and specific size variation are allowed to be packed into a 3D arrangement, which results in an open porosity that improves bone growth. Methods BG-58S macrospheres were produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursors (TEP or phosphoric acid-AF). Macrospheres (MAF-1 M, MAF-2 M, MTEP-1 M, and MTEP-2 M) were characterized as to surface morphology and size, theoretical density, and specific surface area/pore size distribution. In vitro bioactivity was evaluated in simulated body fluid (SBF). In vitro tests were conducted (for MAF-2 M and MTEP-2 M) as cell viability, total protein content, determination of alkaline phosphatase, cell adhesion by means of SEM, and mineralization nodules formation compared to commercial product (BG-45S5). Biological performance was verified through histological and histomorphometric analyses around the samples: BG-45S5, MTEP-2 M, and control (clot). Results All physicochemical characterizations demonstrated favorable macrospheres for application in bone grafting. MTEP-2 M and MAF-2 M showed higher cell viability and total protein content when compared to BG-45S5 with a statisti- cal difference (p < 0.05); however, no statistical difference was detected among the groups regarding the determination of alkaline phosphatase (p > 0.05). Cells adhered to the surface were observed for all samples as well as nodules of minerali- zation. The results referring to in vivo biological assays showed no statistical difference between the experimental groups MTEP-2 M, BV45S5, and clot control in the two periods evaluated (p > 0.05). Conclusion The method used in this study was able to prepare macrosphere bioglass, and this material seems to be a promis- ing biomaterial to improve bone tissue regeneration.
dc.description.physical18 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriCAPES (code 001) FAPESP (2019/15960–6) CNPq (303149/2018–3) Finep (01.13.0275.00 and 01.18.0053.00).
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Estado de São Paulo
dc.identifier.bibliographicCitationGRANCIANINOV, Karen et al. BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor. Research on Biomedical Engineering, v. 39, n. 4, p. 877-894, 2023. Disponível em:
dc.identifier.doi10.1007/s42600-023-00312-9
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/672.2
dc.language.isoen_US
dc.publisherSpringer Nature Link
dc.rights.holderResearch on Biomedical Engineering
dc.subject.keywordBG-58S macrospheres
dc.subject.keywordPhosphorus precursor
dc.subject.keywordAlkali-mediated sol–gel
dc.subject.keywordOsteoblast
dc.subject.keywordBone repair
dc.titleBG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor
dc.typeArtigos de Periódicos

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