Diphenyl diselenide suppresses key virulence factors of Candida krusei, a neglected fungal pathogen

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dc.contributor.authorSilva, Bruna Graziele Marques da
dc.contributor.authorPinto, Ana Paula
dc.contributor.authorPassos, Juliene Cristina da Silva
dc.contributor.authorRocha, João Batista Teixeira da
dc.contributor.authorSilva, Carlos Alberto
dc.contributor.authorCosta, Maricilia Silva
dc.date.accessioned2025-06-10T17:29:12Z
dc.date.available2025-06-10T17:29:12Z
dc.date.issued22022
dc.description.abstractCandida krusei is a candidiasis etiological agent of relevance in the clinical setting because of its intrinsic resistance to fluconazole. Also, it has opened up new paths in the area of alternative therapeutic techniques. This project demonstrated the effects of diphenyl diselenide (PhSe)2 and p-cloro diphenyl diselenide (pCl-PhSe)2, two organochalcogen compounds, on relevant virulence factors for the early stage of the C. krusei host interaction and infection process. Both com- pounds inhibited adherence of C. krusei to both polystyrene surfaces and cervical epithelial cells and biofilm formation; the structure of the biofilm was also changed in a dose-dependent man- ner. In addition, both compounds inhibited C. krusei growth, but (PhSe)2 significantly increased the time duration of the lag phase and delayed the start of the exponential phase in growth kinetics. (PhSe)2 has more potential antifungal activity than (pCl-PhSe)2 in inhibiting the adher- ence to epithelial cells, biofilm formation, and growth of C. krusei.
dc.description.physical15 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.uriCapes (Finance Code 001)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Federal de Santa Maria
dc.identifier.affiliationUniversidade Federal do ABC
dc.identifier.bibliographicCitationSILVA, B. G. M. et al. Diphenyl diselenide suppresses key virulence factors of Candida krusei, a neglected fungal pathogen. Biofouling, v. 38, n. 5, p. 427-440, 2022. Disponível em:
dc.identifier.doi10.1080/08927014.2022.2084388
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/989
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.rights.holderBiofouling
dc.subject.keywordCandida krusei
dc.subject.keywordOrganochalcogen compound
dc.subject.keywordAntifungal activity
dc.subject.keywordAdhesion cell
dc.subject.keywordVirulence factors
dc.titleDiphenyl diselenide suppresses key virulence factors of Candida krusei, a neglected fungal pathogen
dc.typeArtigos de Periódicos

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