Calcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies

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dc.contributor.authorGonçalves, Isabela dos Santos
dc.contributor.authorDonda, Giovanni Moreira
dc.contributor.authorOliveira Filho, Hugo Gutemberg Patino de
dc.contributor.authorFernandes, Marina Santos
dc.contributor.authorBarbosa, Ana Maria
dc.contributor.authorRaniero, Leandro José
dc.contributor.authorVasconcellos, Luana Marotta Reis de
dc.contributor.authorOliveira, Ivone Regina de
dc.date.accessioned2026-01-13T19:44:12Z
dc.date.available2026-01-13T19:44:12Z
dc.date.issued22024
dc.description.abstractHomogeneous calcium aluminate cement–based (CH) materials hold potential as biomaterials, while bioactive glass (BG-58S) is a promising bone regeneration material with excellent bioactivity. Strontium, known for stimulating bone tissue regeneration, was incorporated into CH-BG-58S blends to enhance bioactivity, osteogenesis, and bone tissue repair. Methods Blends with only BG-58S were evaluated for viscosity, injectability, and workability. In vitro tests were performed using MG63 cells and in vivo tests utilized blends CH-7.5BG-58S and CH-7.5BG-58S/Sr to fill monocortical critical bone defects. Bactericidal capacity against Escherichia coli and Staphylococcus aureus was also evaluated. The addition of BG to CH increased viscosity, decreased injectability, and improved workability. Results All blends were non-cytotoxic, and CH-7.5BG-58S and CH-10BG-58S blends exhibited bactericidal capacity against E. coli. Osteogenic activity, confirmed by mineralization nodule formation, was observed in all blends. Histomorphometric and histological analyses revealed bone neoformation, with emphasis on SrO-containing groups, but without statistical significance among groups (p > 0.05). Conclusion This research highlights the potential of CH-BG-58S blends, particularly those with strontium, as bioactive materials for bone tissue engineering.
dc.description.physical12 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriFAPESP: 2016/15032–3 and 2020/16384–6.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.bibliographicCitationGONÇALVES, I. S. et al. Calcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies. Research on Biomedical Engineering, v. 40, n. 3-4, p. 769-780, 2024. Disponível em: https://link.springer.com/10.1007/s42600-024-00378-z.
dc.identifier.doi10.1007/s42600-024-00378-z
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1085
dc.language.isoen_US
dc.publisherSpringer Nature
dc.rights.holderResearch on Biomedical Engineering
dc.subject.keywordCalcium aluminate blends
dc.subject.keywordBioactive glass
dc.subject.keywordStrontium
dc.subject.keywordOsteogenesis
dc.subject.keywordBone repair
dc.titleCalcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies
dc.typeArtigos de Periódicos

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