Biocomposite macrospheres based on strontium-bioactive glass for application as bone fillers

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dc.contributor.authorOliveira, Ivone Regina de
dc.contributor.authorGonçalves, Isabela dos Santos
dc.contributor.authorSantos, Kennedy Wallace dos
dc.contributor.authorLança, Maria Carmo
dc.contributor.authorVieira, Tânia
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorCengiz, Ibrahim Fatih
dc.contributor.authorReis, Rui Luís
dc.contributor.authorOliveira, Joaquim Miguel
dc.contributor.authorBorges, João Paulo Miranda Ribeiro
dc.date.accessioned2025-02-07T17:09:59Z
dc.date.available2025-02-07T17:09:59Z
dc.date.issued22023
dc.description.abstractTraditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which can limit bone ingrowth. The use of novel biocomposite sphere formulations comprising bioactive factors as bone fillers are most advantageous, as it simultaneously allows for packing the particles in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately a superior new bone formation. In this work, we develop and characterize novel biocomposite macrospheres of Sr-bioactive glass using sodium alginate, polylactic acid (PLA), and chitosan (CH) as encapsulating materials for finding applications as bone fillers. The biocomposite macrospheres that were obtained using PLA have a larger size distribution and higher porosity and an interconnectivity of 99.7%. Loose apatite particles were observed on the surface of macrospheres prepared with alginate and CH by means of soaking into a simulated body fluid (SBF) for 7 days. A dense apatite layer was formed on the biocomposite macrospheres’ surface produced with PLA, which served to protect PLA from degradation. In vitro investigations demonstrated that biocomposite macrospheres had minimal cytotoxic effects on a human osteosarcoma cell line (SaOS-2 cells). However, the accelerated degradation of PLA due to the degradation of bioactive glass may account for the observed decrease in SaOS-2 cells viability. Among the biocomposite macrospheres, those composed of PLA exhibited the most promising characteristics for their potential use as fillers in bone tissue repair applications.
dc.description.physical13 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.uriFAPESP (#2019/15960-6) CNPQ (303149/2018-3)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationNOVA University Lisbon
dc.identifier.affiliationUniversity of Minho
dc.identifier.bibliographicCitationOliveira, Ivone Regina de et al. Biocomposite macrospheres based on strontium-bioactive glass for application as bone fillers. ACS Materials Au, v. 3, n. 6, p. 646-658, 2023. Disponível em: https://pubs.acs.org/doi/10.1021/acsmaterialsau.3c00048.
dc.identifier.doi10.1021/acsmaterialsau.3c00048
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/556
dc.language.isoen_US
dc.publisherAmerican Chemical Society
dc.rights.holderIvone Regina de Oliveira
dc.subject.keywordBioactive glass
dc.subject.keywordStrontium
dc.subject.keywordMacrospheres
dc.subject.keywordEncapsulation
dc.subject.keywordBone defects
dc.titleBiocomposite macrospheres based on strontium-bioactive glass for application as bone fillers
dc.typeArtigos de Periódicos

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