Local envenomation caused by a bioactive peptide fraction of Bothrops jararaca snake venom induces leukocyte influx in the lung and changes in pulmonary mechanics

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dc.contributor.authorSilva, Carlos Alberto
dc.contributor.authorQuerobino, Samyr Machado
dc.contributor.authorSilva, Cesar Augusto Melo
dc.contributor.authorCosta, Maricilia Silva
dc.contributor.authorOliveira, Luis Vicente Franco
dc.contributor.authorZamuner, Stella Regina
dc.date.accessioned2025-04-02T18:57:28Z
dc.date.available2025-04-02T18:57:28Z
dc.date.issued22022-01-07
dc.description.abstractThe crude venom of the Bothrops jararaca snake (Bj-CV) is a complex mixture of biologically active proteins that includes a variety of peptides in the low molecular weight fraction (Bj-PF). We investigated how an intramuscular injection of Bj-CV (1.2 mg kg−1) and Bj-PF (0.24 mg kg−1) influenced lung mechanics and lung and muscle inflammation in male Swiss mice 15 min, 1, 6, and 24 h after inoculation. Pressure dissipation against lung resistive components (ΔP1) rose significantly from 1 to 24 h after Bj-CV and 6–24 h after Bj-PF inoculation. Both Bj-CV and Bj-PF increased the total pressure variation of the lung (ΔPtot) 24 h after injection. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Lung static elastance increased significantly after injection in all time periods investigated by Bj-CV and from 6 to 24 h by Bj-PF. Furthermore, intramuscular inoculation of Bj-CV and Bj-PF resulted in an increase in muscle and pulmonary inflammation, as evidenced by an increase in leukocyte influx when compared to the control group. Finally, both Bj-CV and Bj-PF cause acute lung injury, as shown by pulmonary inflammation and decreased lung mechanics. Furthermore, the fact that Bj-PF produces mechanical alterations in the lungs and muscular inflammation implies that non-enzymatic compounds can cause inflammation.
dc.description.physical8 p.
dc.format.mimetypepdf
dc.identifier.affiliationNatural and Humanities Sciences Center, Experimental Morphophysiology Laboratory Federal University of ABC (UFABC)
dc.identifier.affiliationMinas Gerais State University (UEMG), Health and Biological Sciences Nucleus
dc.identifier.affiliationLaboratory of Respiratory Physiology, University of Brasilia
dc.identifier.affiliationInstituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba- UNIVAP
dc.identifier.affiliationPós Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias
dc.identifier.affiliationPostgraduate Program in Medicine, Universidade Nove de Julho – UNINOVE
dc.identifier.bibliographicCitationALBERTO-SILVA, C. et al. Local envenomation caused by a bioactive peptide fraction of Bothrops jararaca snake venom induces leukocyte influx in the lung and changes in pulmonary mechanics. Toxicon, [S. l.], v. 207, p. 52–59, fev. 2022. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0041010122000010.
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2022.01.001
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/798
dc.language.isoen
dc.publisherElsevier
dc.rights.holderCarlos Alberto-Silva
dc.rights.holderSamyr Machado Querobino
dc.rights.holderCesar Augusto Melo-Silva
dc.rights.holderMaricilia Silva Costa
dc.rights.holderLuis Vicente Franco Oliveira
dc.rights.holderStella Regina Zamuner
dc.subject.keywordBothrops jararaca
dc.subject.keywordFT-IR spectroscopy
dc.subject.keywordLung inflammation
dc.subject.keywordPeptide fraction
dc.subject.keywordPulmonary mechanic
dc.subject.keywordSnake venom
dc.titleLocal envenomation caused by a bioactive peptide fraction of Bothrops jararaca snake venom induces leukocyte influx in the lung and changes in pulmonary mechanics
dc.typeArtigos de Periódicos

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