Biochemical changes in Leishmania braziliensis after photodynamic therapy with methylene blue assessed by the Fourier transform infrared spectroscopy

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dc.contributor.authorSakane, Kumiko Koibuchi
dc.contributor.authorBhattacharjee, Tanmoy
dc.contributor.authorFagundes, Jaciara
dc.contributor.authorMarcolino, Luciana Maria Cortez
dc.contributor.authorFerreira, Isabelle
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorFerreira-Strixino, Juliana
dc.date.accessioned2025-06-11T12:46:07Z
dc.date.available2025-06-11T12:46:07Z
dc.date.issued22021
dc.description.abstractPhotodynamic therapy (PDT) with photosensitizer methylene blue was applied to Leishmania braziliensis, and Fourier transform infrared (FTIR) spectroscopy was used to study biochemical changes in the parasite after PDT in comparison to untreated (C), only irradiation (I), and only photosensitizer (PS). Spectral analysis suggests increase in lipids, proteins, and protein secondary structures in PDT compared with C and decrease in nucleic acids and carbohydrates. Interestingly, these trends are different from PDT of Leishmania major species, wherein lipids decrease; there are minimal changes in secondary structures and increase in nucleic acids and carbohydrates. The study thus suggests possibility of different biomolecular players/pathways in PDT-induced death of L. braziliensis and L. major.
dc.description.physical7 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriFAPESP (2016/12211-4) CAPES (Finance Code 001)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationSir John Walsh Research Institute
dc.identifier.bibliographicCitationSAKANE, K. K. et al. Biochemical changes in Leishmania braziliensis after photodynamic therapy with methylene blue assessed by the Fourier transform infrared spectroscopy. Lasers in Medical Science, v. 36, n. 4, p. 821-827, 2021. Disponível em: https://link.springer.com/10.1007/s10103-020-03110-2.
dc.identifier.doi10.1007/s10103-020-03110-2
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/992
dc.language.isoen_US
dc.publisherSpringer Nature Link
dc.rights.holderLasers in Medical Science
dc.subject.keywordLeishmania braziliensis
dc.subject.keywordMethylene blue
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordFTIR spectroscopy
dc.titleBiochemical changes in Leishmania braziliensis after photodynamic therapy with methylene blue assessed by the Fourier transform infrared spectroscopy
dc.typeArtigos de Periódicos

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