Photodynamic therapy using silicon phthalocyanine conjugated with bovine serum albumin as a drug delivery system

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dc.contributor.authorSilva, Emanoel Pedro de Oliveira
dc.contributor.authorRibeiro, Natalia Mazini
dc.contributor.authorCardoso, Maria Angélica Gargione
dc.contributor.authorPacheco-Soares, Cristina
dc.contributor.authorBeltrame Junior, Milton
dc.date.accessioned2025-06-13T13:58:23Z
dc.date.available2025-06-13T13:58:23Z
dc.date.issued22021
dc.description.abstractIn the present study, we describe a new silicon phthalocyanine conjugated to bovine serum albumin (PcSiN3M-BSA) and its photodynamic activity in murine macrophages cells (J774.A1). The nonconjugated precursor, bis(trimethylaminoethanoxy)–phthalocyaninato silicon (IV) (PcSiN3M), was also studied. Compounds PcSiN3M and PcSiN3M-BSA showed no cytotoxicity in the dark, but exhibited high photodynamic activities following exposure to 5 μM photosensitizers and 45 J cm−2 irradiation. These conditions were sufficient to decrease the cell viability to 40% and 5% in cells treated with PcSiN3M and PcSiN3M-BSA, respectively. These results demonstrated an increase of 87% in the photodynamic activity of PcSiN3M when conjugated with BSA. The results shown in this work suggest that PcSiN3M-BSA had higher uptake by J774.A1 cells, which contributed to its higher photoactivity compared with the unconjugated form, PcSiN3N.
dc.description.physical8 p.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationSILVA, E. P. O. et al. Photodynamic therapy using silicon phthalocyanine conjugated with bovine serum albumin as a drug delivery system. Laser Physics, v. 31, n. 7, p.1-7, 2021. Disponível em:
dc.identifier.doi10.1088/1555-6611/abfe58
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1003
dc.language.isoen_US
dc.publisherIOP science
dc.rights.holderLaser Physics
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordPhthalocyanines
dc.subject.keywordBovine serum albumin
dc.subject.keywordMurine macrophages cells
dc.titlePhotodynamic therapy using silicon phthalocyanine conjugated with bovine serum albumin as a drug delivery system
dc.typeArtigos de Periódicos

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