From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model

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dc.contributor.authorBrandão, Ana Beatriz Pereira
dc.contributor.authorAlbuquerque, Raquel Cristina Melo Ferreira de
dc.contributor.authorAbreu, Isabel Cristina Mallosto Emerich de
dc.contributor.authorFerreira, Fabiana Gomes
dc.contributor.authorSantos, Leticia Barssotti dos
dc.contributor.authorJensen, Leonardo
dc.contributor.authorSouza, Leandro Eziquiel de
dc.contributor.authorFerreira, Sarah Gomes
dc.contributor.authorSouza, Lívia Bruni de
dc.contributor.authorArisawa, Emilia Angela Lo Schiavo
dc.contributor.authorSant′Anna, Luciana Barros
dc.contributor.authorHiga, Elisa Mieko Suemitsu
dc.contributor.authorCasali, Adenauer Girardi
dc.contributor.authorAimbire, Flávio
dc.contributor.authorIrigoyen, Maria Claudia Costa
dc.contributor.authorCasali, Karina Rabello
dc.contributor.authorCunha, Tatiana Sousa
dc.date.accessioned2026-02-13T12:35:18Z
dc.date.available2026-02-13T12:35:18Z
dc.date.issued22026
dc.description.abstractBackground: We investigated whether the probiotic yeast Saccharomyces boulardii confers cardiometabolic protection and prevents diabetic cardiomyopathy by modulating inflammation, cardiac remodelling, cardiovascular function, and autonomic regulation. Methods: Male C57BL/6 mice were allocated into four groups: Control (C), Diabetes (DM), Control+Saccharomyces boulardii (CSb), and Diabetes+Saccharomyces boulardii (DMSb). Diabetes was induced with intraperitoneal streptozotocin (STZ), and treatments (sterile water or Saccharomyces boulardii) were administered orally for 8weeks. Blood glucose, cytokines, and nitric oxide levels were measured, along with cardiac function via echocardiography and direct blood pressure recordings. Results: Saccharomyces boulardii reduced blood glucose and increased cardiac IL-10 in diabetic mice, restoring nitric oxide levels. These effects were associated to reduced collagen deposition, preventing vascular damage and ventricular fibrosis, and were accompanied by improved systolic/ diastolic function and autonomic control. Conclusion: Saccharomyces boulardii improved cardiac structure, function, and autonomic control in diabetic mice, supporting its potential as adjunct therapy for diabetic cardiomyopathy.
dc.description.physical14 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriFAPESP: 2016/24059–2
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Federal de São Paulo
dc.identifier.affiliationUniversidade Estadual de Campinas
dc.identifier.affiliationUniversidade de São Paulo
dc.identifier.bibliographicCitationBRANDÃO, A. B. P. et al. From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model. Archives of Physiology and Biochemistry, v. 132, n. 1, p. 65-78, 2026. Disponível em: 10.1080/13813455.2025.2539188.
dc.identifier.doi10.1080/13813455.2025.2539188
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1150
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.rights.holderArchives of Physiology and Biochemistry
dc.subject.keywordProbiotic
dc.subject.keywordDiabetes
dc.subject.keywordAutonomic modulation
dc.subject.keywordNitric oxide
dc.subject.keywordCardiac hypertrophy
dc.titleFrom the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model
dc.typeArtigos de Periódicos

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