Therapeutic Potential of Photobiomodulation in Early Recovery After Experimental Spinal Cord Injury in Rats: Histological and Biomechanical Analysis

Página do item simplificado
dc.contributor.authorCorreia, Débora Campos Chaves
dc.contributor.authorLima, Leonardo Borges de
dc.contributor.authorLima, Mário Oliveira
dc.contributor.authorBeloni, Luís Filipe Karatanasov
dc.contributor.authorHage, Raduan
dc.contributor.authorArisawa, Emilia Angela Lo Schiavo
dc.date.accessioned2026-01-13T14:41:38Z
dc.date.available2026-01-13T14:41:38Z
dc.date.issued22025
dc.description.abstractSpinal cord injury (SCI) leads to severe functional deficits, underscoring the critical need for new therapies. This study evaluated the efficacy of photobiomodulation (PBM) as an early, noninvasive treatment for induced SCI, using specific parameters (808 nm, 72J/cm2, 100mW). A total of 15 rats were divided into Control (C), SCI, and PBM groups. Efficacy was determined by an inte- grated approach, correlating ground reaction force (GRF) with quantitative histological assessment. The PBM group showed a significant reduction of secondary damage (33.3 ± 5.5 vs. 53.9 ± 7.0 in the SCI group; p = 0.0002) and preserved neural structure. This tissue preservation aligns with the GRF analysis, which demonstrated that the PBM group recovered gait patterns similar to the Control group. In conclusion, PBM effectively mitigates necrosis aerea, maintaining tissue integrity, improving functional recovery, and reinforcing the PBM's therapeutic potential as a promising translatable strategy for outcomes after SCI. Further research should include immunostaining of cells and larger samples.
dc.description.physical10 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationCORREIA, D. C. C. et al. Therapeutic Potential of Photobiomodulation in Early Recovery After Experimental Spinal Cord Injury in Rats: Histological and Biomechanical Analysis. Journal of Biophotonics, p. 1-10, 2025. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jbio.202500348.
dc.identifier.doi10.1002/jbio.202500348
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1081
dc.language.isoen_US
dc.publisherWiley
dc.rights.holderJournal of Biophotonics
dc.subject.keywordNervous system
dc.subject.keywordNeuroprotection
dc.subject.keywordPhotobiomodulation
dc.subject.keywordSpinal cord injury
dc.titleTherapeutic Potential of Photobiomodulation in Early Recovery After Experimental Spinal Cord Injury in Rats: Histological and Biomechanical Analysis
dc.typeArtigos de Periódicos

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Therapeutic Potential of Photobiomodulation in Early.pdf
Tamanho:
1 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

Produção acadêmica-PPGEB