Bioabsorbable Poly(vinyl alcohol)–Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model

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dc.contributor.authorPereira, Jonalba Mendes
dc.contributor.authorArisawa, Emilia Angela Lo Schiavo
dc.contributor.authorMaia Filho, Antônio Luiz Martins
dc.contributor.authorSilva, José Figueredo
dc.contributor.authorAlves, Nicoly
dc.contributor.authorSilveira, Carolina Hahn da
dc.contributor.authorVieira, Lucia
dc.date.accessioned2026-01-13T14:05:36Z
dc.date.available2026-01-13T14:05:36Z
dc.date.issued22025
dc.description.abstractBackground: The wound healing process presents notable challenges for nurs- ing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combi- nation promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action. Methods: The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats (n = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing. Results: The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA- CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely. Conclusions: The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing in- flammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds.
dc.description.physical13 p.
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Estado do Piauí
dc.identifier.bibliographicCitationPEREIRA, J. M. et al. Bioabsorbable Poly(vinyl alcohol)–Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model. European Burn Journal, v. 6, n. 2, p. 1-13, 2025. Disponível em: https://www.mdpi.com/2673-1991/6/2/18.
dc.identifier.doi10.3390/ebj6020018
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1078
dc.language.isoen_US
dc.publisherMDPI
dc.rights.holderEuropean Burn Journal
dc.subject.keywordDressings
dc.subject.keywordBioabsorbable
dc.subject.keywordWound healing
dc.subject.keywordPolyvinyl alcohol–citric acid
dc.titleBioabsorbable Poly(vinyl alcohol)–Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model
dc.typeArtigos de Periódicos

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