Anti‐inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan‐induced inflammation

Página do item simplificado
dc.contributor.authorSilva, Carlos Alberto
dc.contributor.authorCalvi, Gabriela de Souza
dc.contributor.authorFeliciano, Regiane dos Santos
dc.contributor.authorSilva Junior, José Antônio
dc.contributor.authorCosta, Maricilia Silva
dc.date.accessioned2026-01-28T14:30:04Z
dc.date.available2026-01-28T14:30:04Z
dc.date.issued22025
dc.description.abstractPurpose Photobiomodulation (PBM) has been suggested as a potential anti-inflammatory therapy, presenting excellent outcomes for several disorders. Reduction in COX-2 mRNA expression in subplantar and brain tissues by PBM was dem- onstrated, using the classic model of oedema formation and hyperalgesia induced by Carrageenan (Carr). This work inves- tigated the effect of PBM on mRNA expression of key inflammation-related genes (IL-1β, mPGES-1, mPGES-2 and EP) in subplantar and brain tissues obtained from rats receiving Carr. Methods The animals were treated with Carr, treated with PBM after 1 h and sacrificed after 1, 3 and 6 h. The light source used was a diode laser, with output power of 30 mW and a wavelength of 660 nm. The laser beam illuminated an area of 0.785 cm2, resulting in an energy dosage of 7.5 J/cm2, applied for 196 s. IL-1β, mPGES-1, mPGES-2 and EP mRNAs were determined by RT-PCR. Results It was observed a reduction in IL-1β expression as in subplantar tissue as in brain parenchyma in animals treated with PBM. In addition, the expression of both mPGES-1 and mPGES-2 mRNA was decreased after PBM. Conclusion These results suggested that PBM could reduce the production of IL-1β and subsequently decreasing the effects of PGE2. Therefore, the possible mechanism by which PBM alleviates hyperalgesia could involve its ability to decrease the expression of inflammatory markers in the CNS, reducing the production of PGE2 in the spinal cord.
dc.description.physical6 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade Nove de Julho
dc.identifier.bibliographicCitationSILVA, C. A. et al. Anti‐inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan‐induced inflammation. Lasers in Medical Science, v. 40. n. 1, p. 1-6, 2025. Disponível em: https://link.springer.com/article/10.1007/s10103-024-04205-w.
dc.identifier.doi10.1007/s10103-024-04205-w
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1109
dc.language.isoen_US
dc.publisherSpringer
dc.rights.holderLasers in Medical Science
dc.subject.keywordPeripheral inflammation model
dc.subject.keywordCarrageenan
dc.subject.keywordInflammatory mediators
dc.subject.keywordPhotobiomodulation
dc.titleAnti‐inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan‐induced inflammation
dc.typeArtigos de Periódicos

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Anti-inflammatory effect of photobiomodulation in the brain.pdf
Tamanho:
1.24 MB
Formato:
Adobe Portable Document Format
Descrição:
Acesso via Portal Capes
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

Produção acadêmica-PPGEB