Hyaluronic Acid-Bupivacaine Hydrogel System for Temporomandibular Joint disorders: Mechanical Lubrification and Local Anesthesia in a preclinical approach

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dc.contributor.authorMiranda, Diego Garcia
dc.contributor.authorRamos, Lucas de Paula
dc.contributor.authorAraujo, Gabriela Ferraz de
dc.contributor.authorLopes, Nicole Fernanda dos Santos
dc.contributor.authorSani-Taiariol, Thalita
dc.contributor.authorBaldan, Mauricio Ribeiro
dc.contributor.authorGodoi, Bruno Henrique
dc.contributor.authorPacheco-Soares, Cristina
dc.contributor.authorGritsch, Kerstin
dc.contributor.authorBorges, Alexandre Luiz Souto
dc.contributor.authorGrosgogeat, Brigitte
dc.date.accessioned2026-07-24T17:36:24Z
dc.date.available2026-07-24T17:36:24Z
dc.date.issued22026-09
dc.description.abstractTemporomandibular disorders (TMD) are primarily characterized by pain and impaired mobility, affecting 5-12% of the adult population and significantly compromising quality of life. Current therapeutic management is multimodal but suffers from high failure rates, highlighting the need for improved interventions. We hypothesized the combination of hyaluronic acid (HA) with bupivacaine (BUP) in the search for a cytocompatibility hydrogel with improved physicochemical properties, suitable for intra-articular therapy of TMD, aiming at physical action, with the viscosity of HA and the prolonged analgesic effects of BUP in a single platform. FTIR analysis confirmed the presence of functional groups of both components. TGA revealed that the HA matrix significantly increased the thermal stability of BUP, delaying its decomposition. Rheological tests demonstrated predominant viscoelastic behavior (G' > G''), with adjustable stiffness depending on the concentration of BUP. Cytocompatibility assays on RAW 264.7 cells (OECD 129) showed that the HA-BUP formulation-maintained cell viability above 98%, in contrast to the use of the anesthetic (BUP) alone (53.6%), and did not exhibit genotoxicity (OECD 487). These findings conclude that the HA-BUP hydrogel has adequate biomechanical, thermal, and biocompatible properties in the laboratory setting. In vivo and clinical studies are needed to evaluate long-term efficacy and safety
dc.description.physical12 p.
dc.format.mimetypepdf
dc.identifier.affiliationUniversité Claude Bernard Lyon
dc.identifier.affiliationUniversidade Federal de Alfenas
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.affiliationInstituto Nacional de Pesquisas Espaciais
dc.identifier.affiliationInstituto Nacional de Pesquisas Espaciais
dc.identifier.affiliationUniversidade do Vale do Paraiba
dc.identifier.affiliationUniversidade do Vale do Paraiba
dc.identifier.affiliationUniversity Claude Bernard Lyon
dc.identifier.affiliationUniversidade Estadual Paulista
dc.identifier.affiliationUniversity Claude Bernard Lyon
dc.identifier.bibliographicCitationMIRANDA, Diego Garcia; RAMOS, Lucas de Paula; ARAUJO, Gabriela Ferraz de; LOPES, Nicole Fernanda dos Santos; SANI-TAIARIOL, Thalita; BALDAN, Mauricio Ribeiro; GODOI, Bruno Henrique; PACHECO-SOARES, Cristina; GRITSCH, Kerstin; BORGES, Alexandre Luiz Souto; GROSGOGEAT, Brigitte. Hyaluronic Acid-Bupivacaine Hydrogel System for Temporomandibular Joint disorders: Mechanical Lubrification and Local Anesthesia in a preclinical approach. Carbohydrate Polymer Technologies and Applications, [S.l.], v. 15, p. 101187, set. 2026. DOI: https://doi.org/10.1016/j.carpta.2026.101187. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2666893926001040.
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/1288
dc.language.isoen
dc.publisherElsevier
dc.rights.holderDiego Garcia Miranda
dc.rights.holderLucas de Paula Ramos
dc.rights.holderGabriela Ferraz de Araujo
dc.rights.holderNicole Fernanda dos Santos Lopes
dc.rights.holderThalita Sani-Taiariol
dc.rights.holderMauricio Ribeiro Baldan
dc.rights.holderBruno Henrique Godoi
dc.rights.holderCristina Pacheco Soares
dc.rights.holderKerstin Gritsch
dc.rights.holderAlexandre Luiz Souto Borges
dc.rights.holderBrigitte Grosgogeat
dc.subject.keywordHydrogels
dc.subject.keywordHyaluronic acid
dc.subject.keywordAnesthetics
dc.subject.keywordTemporomandibular disorders
dc.titleHyaluronic Acid-Bupivacaine Hydrogel System for Temporomandibular Joint disorders: Mechanical Lubrification and Local Anesthesia in a preclinical approach
dc.typeArtigos de Periódicos

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