Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo

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dc.contributor.authorMeccatti, Vanessa Marques
dc.contributor.authorMoura, Larissa de Souza
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorFerreira‐Strixino, Juliana
dc.contributor.authorHasna, Amjad Abu
dc.contributor.authorFigueiredo-Godoi, Lívia Mara Alves
dc.contributor.authorJunqueira, Juliana Campos
dc.contributor.authorMarcucci, María Cristina
dc.contributor.authorRamos, Lucas de Paula
dc.contributor.authorCarvalho, Cláudio Antônio Talge
dc.contributor.authorPucci, César Rogério
dc.contributor.authorOliveira, Luciane Dias de
dc.date.accessioned2025-04-01T13:42:49Z
dc.date.available2025-04-01T13:42:49Z
dc.date.issued22023-07-01
dc.description.abstractRadiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.
dc.description.physical6 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.mimetypepdf
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.affiliationUnesp
dc.identifier.bibliographicCitationMARQUES MECCATTI, V. et al. Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo. International Journal of Dentistry, [S. l.], v. 2022, p. 1–6, 1 jul. 2022. Disponível em: https://www.hindawi.com/journals/ijd/2022/5837864/.
dc.identifier.doi10.1155/2022/5837864
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/792
dc.language.isoen_US
dc.publisherWiley Online Library
dc.rights.holderVanessa Marques Meccatti
dc.rights.holderLarissa de Souza Moura
dc.rights.holderJuliana Guerra Pinto
dc.rights.holderJuliana Ferreira‐Strixino
dc.rights.holderAmjad Abu Hasna
dc.rights.holderLívia Mara Alves Figueiredo-Godoi
dc.rights.holderJuliana Campos Junqueira
dc.rights.holderMaría Cristina Marcucci
dc.rights.holderLucas de Paula Ramos
dc.rights.holderCláudio Antônio Talge Carvalho
dc.rights.holderCésar Rogério Pucci
dc.rights.holderLuciane Dias de Oliveira
dc.subject.keywordCandida spp
dc.subject.keywordCurcuma
dc.titleCurcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
dc.typeArtigos de Periódicos

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