Vaterite microparticle-loaded methylene blue for photodynamic activity in macrophages infected with Leishmania braziliensis

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dc.contributor.authorMarmo, Vitor Luca Moura
dc.contributor.authorAmbrósio, Jéssica Aparecida Ribeiro
dc.contributor.authorGonçalves, Érika Peterson
dc.contributor.authorRaniero, Leandro José
dc.contributor.authorBeltrame Junior, Milton
dc.contributor.authorPinto, Juliana Guerra
dc.contributor.authorFerreira-Strixino, Juliana
dc.contributor.authorSimioni, Andreza Ribeiro
dc.date.accessioned2025-03-21T14:46:36Z
dc.date.available2025-03-21T14:46:36Z
dc.date.issued22023-04-28
dc.description.abstractCalcium carbonate (CaCO3) exhibits a variety of crystalline phases, including the anhydrous crystalline polymorphs calcite, aragonite, and vaterite. Developing porous calcium carbonate microparticles in the vaterite phase for the encapsulation of methylene blue (MB) as a photosensitizer (PS) for use in photodynamic therapy (PDT) was the goal of this investigation. Using an adsorption approach, the PS was integrated into the CaCO3 microparticles. The vaterite microparticles were characterized by scanning electron microscopy (SEM) and steady-state techniques. The trypan blue exclusion method was used to measure the biological activity of macrophages infected with Leishmania braziliensis in vitro. The vaterite microparticles produced are highly porous, non-aggregated, and uniform in size. After encapsulation, the MB-loaded microparticles kept their photophysical characteristics. The carriers that were captured allowed for dye localization inside the cells. The results obtained in this study indicated that the MB-loaded vaterite microparticles show promising photodynamic activity in macrophages infected with Leishmania braziliensis.
dc.description.physical13 p.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.uriFAPESP project number 2018/18531-6.
dc.format.mimetypepdf
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.bibliographicCitationMARMO, V. L. M. et al. Vaterite microparticle-loaded methylene blue for photodynamic activity in macrophages infected with Leishmania braziliensis. Photochemical & Photobiological Sciences, [S. l.], v. 22, n. 8, p. 1977–1989, ago. 2023. Disponível em: https://link.springer.com/10.1007/s43630-023-00426-0..
dc.identifier.doi10.1007/s43630-023-00426-0
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/739
dc.language.isoen_US
dc.publisherSpringer Nature
dc.rights.holderEuropean Photochemistry Association, European Society for Photobiology
dc.subject.keywordMethylene blue
dc.subject.keywordVaterite
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordLeishmania
dc.titleVaterite microparticle-loaded methylene blue for photodynamic activity in macrophages infected with Leishmania braziliensis
dc.typeArtigos de Periódicos

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