BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor

Página do item simplificado
dc.contributor.authorGrancianinov, Karen
dc.contributor.authorSantos, Kennedy dos
dc.contributor.authorGonçalves, Isabela
dc.contributor.authorDonda, Giovanni
dc.contributor.authorLauda, Diogo
dc.contributor.authorAmaral, Suelen
dc.contributor.authorSouza, Amanda
dc.contributor.authorVasconcellos, Luana de
dc.contributor.authorOliveira, Ivone Regina de
dc.date.accessioned2025-03-11T14:29:40Z
dc.date.available2025-03-11T14:29:40Z
dc.date.issued22024
dc.description.abstractPurpose Bioactive glass (BG) spheres with uniform shape and specific size variation are allowed to be packed into a 3D arrangement, which results in an open porosity that improves bone growth. Methods BG-58S macrospheres were produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursors (TEP or phosphoric acid-AF). Macrospheres (MAF-1 M, MAF-2 M, MTEP-1 M, and MTEP-2 M) were characterized as to surface morphology and size, theoretical density, and specific surface area/pore size distribution. In vitro bioactivity was evaluated in simulated body fluid (SBF). In vitro tests were conducted (for MAF-2 M and MTEP-2 M) as cell viability, total protein content, determination of alkaline phosphatase, cell adhesion by means of SEM, and mineralization nodules formation compared to commercial product (BG-45S5). Biological performance was verified through histological and histomorphometric analyses around the samples: BG-45S5, MTEP-2 M, and control (clot). Results All physicochemical characterizations demonstrated favorable macrospheres for application in bone grafting. MTEP-2 M and MAF-2 M showed higher cell viability and total protein content when compared to BG-45S5 with a statisti- cal difference (p < 0.05); however, no statistical difference was detected among the groups regarding the determination of alkaline phosphatase (p > 0.05). Cells adhered to the surface were observed for all samples as well as nodules of minerali- zation. The results referring to in vivo biological assays showed no statistical difference between the experimental groups MTEP-2 M, BV45S5, and clot control in the two periods evaluated (p > 0.05). Conclusion The method used in this study was able to prepare macrosphere bioglass, and this material seems to be a promis- ing biomaterial to improve bone tissue regeneration.
dc.description.physical18 p.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (Finep)
dc.description.uriCAPES (code 001) FAPESP (2019/15960–6) CNPq (303149/2018–3) Finep (01.13.0275.00 and 01.18.0053.00).
dc.format.mimetypePDF
dc.identifier.affiliationUniversidade do Vale do Paraíba
dc.identifier.affiliationUniversidade do Estado de São Paulo
dc.identifier.bibliographicCitationGRANCIANINOV, Karen et al. BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor. Research on Biomedical Engineering, v. 39, n. 4, p. 877-894, 2023. Disponível em:
dc.identifier.doi10.1007/s42600-023-00312-9
dc.identifier.urihttps://repositorio.univap.br/handle/123456789/672
dc.language.isoen_US
dc.publisherSpringer Nature Link
dc.rights.holderResearch on Biomedical Engineering
dc.subject.keywordBG-58S macrospheres
dc.subject.keywordPhosphorus precursor
dc.subject.keywordAlkali-mediated sol–gel
dc.subject.keywordOsteoblast
dc.subject.keywordBone repair
dc.titleBG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor
dc.typeArtigos de Periódicos

Arquivos

Pacote Original
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
BG-58S macrospheres produced using BG powder synthesized by alkali-mediated sol–gel process and different phosphorus precursor.pdf
Tamanho:
2.75 MB
Formato:
Adobe Portable Document Format
Descrição:
Acesso via CAPES
Baixar
Nenhuma Miniatura disponível
Nome:
BG-58S macrospheres produced using BG powder synthesized by.pdf
Tamanho:
444.41 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

Produção acadêmica-PPGPLUR

Histórico de Versões

Agora exibindo 1 - 2 de 2
VersãoDataSumário
2
 2025-03-11 11:31:35
artigo com documento na íntegra
1*
 2025-03-11 11:29:40
* Versão selecionada